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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Influence of apoptosis on liver and spleen resistance in dogs with visceral leishmaniosis

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Reina Moreira, Pamela Rodrigues ; Franciscato, Douglas Augusto ; Rossit, Sabrina Micelli ; Munari, Danisio Prado ; Vasconcelos, Rosemeri de Oliveira
Total Authors: 5
Document type: Journal article
Source: Revista Brasileira de Parasitologia Veterinária; v. 25, n. 3, p. 341-347, JUL-SEP 2016.
Web of Science Citations: 2

The aim of this study was to evaluate apoptosis and parasite load in the liver and spleen of dogs with visceral leishmaniosis (VL), using immunohistochemistry. Liver and spleen samples from 71 dogs with VL were used. The parasite load in the spleen and liver showed significant difference between organs in infected group (P=0.0219). The density of the parasite load in the spleen (median=2.4) was higher than liver (median=0.8). Immunodetection of apoptotic cells was predominant in lymphocytes and differ between the infected and control group in spleen (P=0.0307) and liver (P=0.0346). There was a significant correlation between apoptosis and parasite load (P=0.0084; r=0.3104) only in the spleen of the infected group, where it was observed that, when increasing the number of apoptotic cells increases the parasitic load. It was concluded that the liver and spleen of infected dogs presented greater numbers of cells undergoing apoptosis (lymphocytes) than the control group, thus suggesting that this process may be contributing towards the survival of Leishmania in these organs, because lymphocyte in apoptosis did not have the ability to present and recognize the antigen, allowing the survival of the parasite. (AU)

FAPESP's process: 09/15736-7 - Hepatic natural killer cells (PIT) action in liver of dogs with visceral leishmaniasis
Grantee:Pamela Rodrigues Reina Moreira
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 09/07815-4 - MIF, iNOS and MHC class II expression in macrophages of lymph nodes of the dogs with visceral leishmaniasis
Grantee:Rosemeri de Oliveira Vasconcelos
Support type: Regular Research Grants