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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Angiotensin II acting on PVN induces sympathoexcitation and pressor responses via the PI3K-dependent pathway

Full text
Author(s):
Buttler, L. ; Ribeiro, I. M. ; Ferreira-Neto, H. C. ; Antunes, V. R.
Total Authors: 4
Document type: Journal article
Source: AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL; v. 198, p. 54-58, JUL 2016.
Web of Science Citations: 1
Abstract

In vitro studies have shown that angiotensin II (ANG II), via activation of ANG II type 1 (AT(1)) receptor plays an important role on the neural control of the blood pressure (BP), through an intracellular signalling pathway involving PI3K in the paraventricular nucleus of the hypothalamus (PVN). However, to the best of our knowledge, no in vivo study has been performed yet to unravel the functional role of ANG II and its interaction with PI3K(pathways in the neural control of circulation of non-anesthetized animals. Here, we demonstrate that exogenous ANG II microinjected into the PVN in anaesthetic-free animals evokes an increase in sympathetic nerve activity and BP in a PI3K-dependent manner. (C) 2016 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 09/01827-0 - Evaluation of PI3K expression and its interaction with angiotensin on central autonomic nuclei of hipertensive animals
Grantee:Leila Buttler
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 10/05037-1 - Role of purinergic receptors of paraventricular nucleus of the hypothalamus in the neurogenic hypertension
Grantee:Hildebrando Candido Ferreira Neto
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 10/17997-0 - Purinergic mechanisms at the hypothalamus level on sympathetic outflow and its correlation to neurogenic hypertension
Grantee:Vagner Roberto Antunes
Support Opportunities: Regular Research Grants
FAPESP's process: 13/06206-0 - Gene expression changes of neuropeptides and proinflammatory factors of the hypothalamus and brainstem nucleus involved with cardiovascular regulation in diet-induced obesity animals
Grantee:Vagner Roberto Antunes
Support Opportunities: Regular Research Grants