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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Imiquimod treatment for Equus caballus papillomavirus infection in equine aural plaques

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Zakia, Luiza S. ; Olivo, Giovane ; Basso, Roberta M. ; Mira, Juliana ; Herman, Mariana ; Araujo, Jr., Joao P. ; Borges, Alexandre S. ; Oliveira-Filho, Jose P.
Total Authors: 8
Document type: Journal article
Source: VETERINARY DERMATOLOGY; v. 27, n. 3, p. 175+, JUN 2016.
Web of Science Citations: 3

Background - Aural plaques are a dermatopathy associated with Equus caballus papillomavirus (EcPV). This disease affects horses of all ages, genders and breeds, and causes sensitivity of the ears. Hypothesis/Objectives - The aim of this study was to evaluate the clinical efficacy of 5% imiquimod cream for the treatment of aural plaques and to compare the PCR detection of EcPV 3, 4, 5 and 6 before and after treatment. Animals - Eight horses diagnosed with aural plaques (14 ears) were used. Three mares with unilateral aural plaques were used as untreated controls. Methods - Imiquimod cream was applied every 48 h until complete resolution of the aural plaques was observed. Animals were evaluated clinically for 180 days after the end of treatment. PCR for detecting EcPV 3, 4, 5 and 6 was performed using aural plaque biopsies collected before and at 90 days after the end of treatment. Results - Clinical resolution was observed in 93% of the treated ears. Imiquimod treatment promoted the clearance of EcPV in 71.4% of the treated ears. Clinical remission of the aural plaques and changes in EcPV DNA positivity between the first and second biopsies were not observed in the control group. In 75% of horses, sedation was required in order to carry out pretreatment cleaning. Conclusions - The results of this study support the hypothesis that 5% imiquimod cream may be used as an effective treatment for aural plaques in horses. (AU)

FAPESP's process: 13/13973-7 - EcPVs DNA detection in aural plaques samples before and after imiquimod treatment
Grantee:Luiza Stachewski Zakia
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 13/15995-8 - Etiologic study of aural plaque in horses
Grantee:José Paes de Oliveira Filho
Support type: Regular Research Grants