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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Remineralizing Potential of a Low Fluoride Toothpaste with Sodium Trimetaphosphate: An in situ Study

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Author(s):
Takeshita, Eliana M. ; Danelon, Marcelle ; Castro, Luciene P. ; Cunha, Robson F. ; Delbem, Alberto C. B.
Total Authors: 5
Document type: Journal article
Source: Caries Research; v. 50, n. 6, p. 571-578, 2016.
Web of Science Citations: 3
Abstract

Objective: To evaluate the effect of a low-fluoride (F) toothpaste supplemented with sodium trimetaphosphate (TMP) on enamel remineralization in situ. Design: Bovine enamel blocks were selected on the basis of their surface hardness (SH) after caries-like lesions had been induced, and randomly divided into 4 treatment groups, according to the toothpastes used: without F or TMP (placebo); 500 ppm F; 500 ppm F plus 1% TMP; and 1,100 ppm F. The study design was blinded and crossover and performed in 4 phases of 3 days each. Eleven subjects used palatal appliances containing 4 bovine enamel blocks which were treated 3 times per day during 1 min each time, with natural slurries of saliva and toothpaste formed in the oral cavity during tooth-brushing. After each phase, the percentages of surface (%SHR) and subsurface hardness recovery (%.KHNR) were calculated. F, calcium (Ca), and phosphorus (Pi) contents in enamel were also determined. Data were analyzed by 1-way, repeated-measures ANOVA, followed by the Student-Newman-Keuls test (p < 0.05). Results: Toothpaste with 500 ppm F + TMP and 1,100 ppm F showed similar %SHR and %Delta KHNR as well as enamel F, Ca, and Pi concentrations. Conclusion: The addition of TMP to a low-fluoride toothpaste promoted a similar remineralizing capacity to that of a standard ( 1,100 ppm F) toothpaste in situ. (C) 2016 S. Karger AG, Basel (AU)

FAPESP's process: 07/03660-0 - In situ demineralization of enamel in response to a dentifrice with low fluoride content supplemented with phosphate
Grantee:Alberto Carlos Botazzo Delbem
Support Opportunities: Regular Research Grants
FAPESP's process: 07/03254-2 - In situ evaluation of anticariogenic action of dentifrice with low fluoride content and supplemented with phosphate
Grantee:Eliana Mitsue Takeshita
Support Opportunities: Scholarships in Brazil - Doctorate