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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Improved photodynamic activity of a dual phthalocyanine-ALA photosensitiser

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Author(s):
Pavani, Christiane ; Francisco, Claudia M. L. ; Gobo, Nicholas R. S. ; de Oliveira, Kleber T. ; Baptista, Mauricio S.
Total Authors: 5
Document type: Journal article
Source: NEW JOURNAL OF CHEMISTRY; v. 40, n. 11, p. 9666-9671, 2016.
Web of Science Citations: 8
Abstract

A phthalocyanine-ALA conjugate showed an improved photoinduced cell killing efficiency due to the combined action of the phthalocyanine core and protoporphyrin IX, which was biosynthesised intracellularly by using released ALA as a substrate. The intracellular presence of two photosensitisers and their joint excitation induced a synergistic efficiency for cell killing. The construction of photosensitisers that release intracellular ALA holds great potential for the development of more efficient PDT photosensitisers. (AU)

FAPESP's process: 13/07937-8 - Redoxome - Redox Processes in Biomedicine
Grantee:Ohara Augusto
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 12/24092-9 - About the synthesis of Naphthalocyanine derivatives: strategies involving organometallic couplings and Methane[10]annulenes
Grantee:Nicholas Roberto da Silva Gobo
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 09/01524-8 - Photodynamic activity of ALA-funcionalizated phthalocyanines
Grantee:Christiane Pavani
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 13/07276-1 - CEPOF - Optics and Photonic Research Center
Grantee:Vanderlei Salvador Bagnato
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 12/50680-5 - Photosensitization in life sciences
Grantee:Mauricio da Silva Baptista
Support type: Research Projects - Thematic Grants
FAPESP's process: 15/21110-4 - Exploiting photocatalyzed reactions under continuous flow conditions by using porphyrinoid systems: (C-FlowPhotoChem)
Grantee:Kleber Thiago de Oliveira
Support type: Regular Research Grants