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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Isolated and combined effects of photobiomodulation therapy, topical nonsteroidal anti-inflammatory drugs, and physical activity in the treatment of osteoarthritis induced by papain

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Author(s):
Tomazoni, Shaiane Silva ; Pinto Leal-Junior, Ernesto Cesar ; Frigo, Lucio ; Pallotta, Rodney Capp ; Teixeira, Simone ; de Almeida, Patricia ; Bjordal, Jan Magnus ; Brandao Lopes-Martins, Rodrigo Alvaro
Total Authors: 8
Document type: Journal article
Source: Journal of Biomedical Optics; v. 21, n. 10 OCT 2016.
Web of Science Citations: 12
Abstract

Osteoarthritis (OA) is a chronic inflammatory disease and is characterized as a degenerative process. This study aimed to evaluate and compare the effects of a topical nonsteroidal anti-inflammatory drug (NSAID), physical activity, and photobiomodulation therapy (PBMT) applied alone and/or in combination between them in an experimental model of knee OA. OA was induced by injection of papain in the knees of rats. After 21 days, the animals started to be treated with the above treatment. Histological analysis shows that the experimental model of OA induction causes morphological changes consistent with the disease, and among treatments, the PBMT is the most effective for reducing these changes. Moreover, the results demonstrate that PBMT and NSAID reduce the total number of cells in the inflammatory infiltrate (p < 0.05) and PBMT was the most effective for reducing the activity of myeloperoxidase (p < 0.05). Finally, we observed that both NSAID and PBMT were effective for reducing the gene expression of MMP-3 (p < 0.05), but in relation to the gene expression of MMP-13, PBMT was the most effective treatment (p < 0.05). The results of this study indicate that PBMT is the most effective therapy in stopping disease progression, and improving inflammatory conditions observed in OA. (C) 2016 Society of Photo-Optical Instrumentation Engineers (SPIE) (AU)

FAPESP's process: 11/18785-9 - THE EFFECT OF LOW LEVEL LASER, TOPICAL NON STEROIDAL ANTIINFLAMMATORY DRUG AND PHYSICAL ACTIVITY ON PAPAIN-INDUCED OSTEOARTHRITIS
Grantee:Shaiane da Silva Tomazoni
Support Opportunities: Scholarships in Brazil - Doctorate