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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Simplification of Lipase Design in the Enzymatic Kinetic Resolution of Amines by Saturation Transfer Difference NMR

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Silva, Marcio S. ; Pietrobom, Daniel
Total Authors: 2
Document type: Journal article
Source: Journal of the Brazilian Chemical Society; v. 27, n. 10, p. 1918-1923, OCT 2016.
Web of Science Citations: 1

In this work, we demonstrate a nuclear magnetic resonance (NMR) method for racemic amide and lipase interaction as a first-pass design method in the enzymatic kinetic resolution of amines. As a novel adaptation of commonly used protein-ligand screening NMR methodologies, this approach relies upon a lipase-amide interaction wherein the time-consuming is reduced drastically and new insights are produced during the development of biocatalysis reactions. (AU)

FAPESP's process: 14/23362-8 - Nuclear magnetic resonance to design and chiral discrimination of biocatalytic process
Grantee:Márcio Santos da Silva
Support type: Regular Research Grants