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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Peripubertal exposure to environmental enrichment prevents schizophrenia-like behaviors in the SHR strain animal model

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Santos, Camila Mauricio ; Peres, Fernanda Fiel ; Diana, Mariana Cepollaro ; Justi, Veronica ; Suiama, Mayra Akimi ; Santana, Marcela Goncalves ; Abilio, Vanessa Costhek
Total Authors: 7
Document type: Journal article
Source: SCHIZOPHRENIA RESEARCH; v. 176, n. 2-3, p. 552-559, OCT 2016.
Web of Science Citations: 6

Schizophrenia is a highly disabling mental disorder, in which genetics and environmental factors interact culminating in the disease. The treatment of negative symptoms and cognitive deficits with antipsychotics is currently inefficient and is an important field of research. Environmental enrichment (EE) has been suggested to improve some cognitive deficits in animal models of various psychiatric disorders. In this study, we aimed to evaluate a possible beneficial effect of early and long-term exposure to EE on an animal model of schizophrenia, the SHR strain. Young male Wistar rats (control strain) and SHRs (21 post-natal days) were housed for 6 weeks in two different conditions: in large cages (10 animals per cage) containing objects of different textures, forms, colors and materials that were changed 3 times/week (EE condition) or in standard cages (5 animals per cage - Control condition). Behavioral evaluations - social interaction (SI), locomotion, prepulse inhibition of startle (PPI) and spontaneous alternation (SA) - were performed 6 weeks after the end of EE. SHRs presented deficits in PPI (a sensorimotor impairment), SI (mimicking the negative symptoms) and SA (a working memory deficit), and also hyperlocomotion (modeling the positive symptoms). EE was able to reduce locomotion and increase PPI in both strains, and to prevent the working memory deficit in SHRs. EE also increased the number of neurons in the CA1 and CA3 of the hippocampus. In conclusion, EE can be a potential nonpharmacological strategy to prevent some behavioral deficits associated with schizophrenia. (C) 2016 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 11/50740-5 - Prevention in schizophrenia and bipolar disorder from neuroscience to the community: a multiphase, multimodal and translational platform for research and intervention
Grantee:Rodrigo Affonseca Bressan
Support type: Research Projects - Thematic Grants
FAPESP's process: 11/18851-1 - The role of BDNF and its receptors in environmental and pharmacological preventive interventions of schizophrenia in an animal model of the disease: the SHR strain
Grantee:Camila Mauricio Santos
Support type: Scholarships in Brazil - Doctorate