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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Punicalagin promotes human villous trophoblast differentiation

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Chen, Baosheng ; Longtine, Mark S. ; Costa, Maria Laura ; Nelson, D. Michael
Total Authors: 4
Document type: Journal article
Source: Placenta; v. 44, p. 80-82, AUG 2016.
Web of Science Citations: 2

Poor differentiation of trophoblasts is associated with placental dysfunction, predisposing women to multiple pregnancy disorders. Punicalagin, a prominent ellagitannin in pomegranate juice has been shown to exert anti-apoptosis and anti-oxidative effects in human trophoblasts. We hypothesized that punicalagin modulates trophoblast differentiation. We found that punicalagin-treated primary trophoblast showed reduced E-cadherin, higher Syncytin 1, more beta-hCG, and increased GCM1, an upstream regulator of beta-hCG. Punicalagin exposure of villous explants enhanced the number of cytotrophoblasts expressing the proliferation marker Ki67. We conclude that punicalagin enhances trophoblast differentiation and speculate that punicalagin might be used therapeutically in pregnancies at risk for placental dysfunction. (C) 2016 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 14/01925-0 - Biological activities of antigen presenting cells in normal and preeclampsia pregnancy
Grantee:Maria Laura Costa Do Nascimento
Support type: Scholarships abroad - Research