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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Viral Carcinogenesis Beyond Malignant Transformation: EBV in the Progression of Human Cancers

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Author(s):
de Oliveira, Deilson Elgui ; Muller-Coan, Barbara G. ; Pagano, Joseph S.
Total Authors: 3
Document type: Review article
Source: TRENDS IN MICROBIOLOGY; v. 24, n. 8, p. 649-664, AUG 2016.
Web of Science Citations: 21
Abstract

Cancer progression begins when malignant cells colonize adjacent sites, and it is characterized by increasing tumor heterogeneity, invasion and dissemination of cancer cells. Clinically, progression is the most relevant stage in the natural history of cancers. A given virus is usually regarded as oncogenic because of its ability to induce malignant transformation of cells. Nonetheless, oncogenic viruses may also be important for the progression of infection-associated cancers. Recently this hypothesis has been addressed because of studies on the contribution of the Epstein-Barr virus (EBV) to the aggressiveness of nasopharyngeal carcinoma (NPC). Several EBV products modulate cancer progression phenomena, such as the epithelial-mesenchymal transition, cell motility, invasiveness, angiogenesis, and metastasis. In this regard, there are compelling data about the effects of EBV latent membrane proteins (LMPs) and EBV nuclear antigens (EBNAs), as well as nontranslated viral RNAs, such as the EBV-encoded small nonpolyadenylated RNAs (EBERs) and viral microRNAs, notably EBV miR-BARTs. The available data on the mechanisms and players involved in the contribution of EBV infection to the aggressiveness of NPC are discussed in this review. Overall, this conceptual framework may be valuable for the understanding of the contribution of some infectious agents in the progression of cancers. (AU)

FAPESP's process: 14/17326-9 - Effects of LMP1 protein of Epstein-Barr virus isolates B95-8 and M81 in the invasive potential of human carcinoma cells, and regulation of endogenous miRNAs and proteins implicated in cancer progression
Grantee:Deilson Elgui de Oliveira
Support Opportunities: Regular Research Grants