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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Diabetes mellitus, metformin and head and neck cancer

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de Oliveira Figueiredo, Rejane Augusta ; Weiderpass, Elisabete ; Tajara, Eloiza Helena ; Strom, Peter ; Carvalho, Andre Lopes ; de Carvalho, Marcos Brasilino ; Kanda, Jossi Ledo ; Moyses, Raquel Ajub ; Wunsch-Filho, Victor
Total Authors: 9
Document type: Journal article
Source: Oral Oncology; v. 61, p. 47-54, OCT 2016.
Web of Science Citations: 7

Introduction: Diabetes mellitus (DM (Diabetes Mellitus)) is directly associated with some cancers. However, studies on the association between diabetes mellitus and head and neck cancer (HNC (Head and Neck Cancer)) have rendered controversial results. The objective of this study was to evaluate the association between DM and HNC, as well as the impact of metformin use on the risk of HNC. Material and methods: This case-control study was conducted within the framework of the Brazilian Head and Neck Genome Project in 2011-2014. The study included 1021 HNC cases with histologically confirmed squamous cell carcinoma of the head and neck admitted to five large hospitals in Sao Paulo state. A total of 1063 controls were selected in the same hospitals. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using unconditional logistic regression. Results: Diabetic participants had a decreased risk of HNC (OR = 0.68; 95% CI: 0.49-0.95) than nondiabetic participants, and this risk was further decreased among diabetic metformin users (OR = 0.54; 95% CI: 0.29-0.99). Diabetic metformin users that were current smokers (OR = 0.13; 95% CI: 0.04-0.44) or had an alcohol consumption of >40 g/day (OR = 0.31; 95% CI: 0.11-0.88) had lower risk of HNC than equivalent non-diabetic participants. Conclusion: The risk of HNC was decreased among diabetic participants; metformin use may at least partially explain this inverse association. (C) 2016 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 10/51168-0 - Environmental, clinical, histopathological and molecular factors associated with development and prognosis of head and neck squamous cell carcinomas
Grantee:Eloiza Helena Tajara da Silva
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 13/20548-0 - Diabetes mellitus and head and neck cancer
Grantee:Victor Wünsch Filho
Support Opportunities: Regular Research Grants
FAPESP's process: 13/21702-3 - Diabetes mellitus and head and neck cancer
Grantee:Rejane Augusta de Oliveira Figueiredo
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 14/18893-4 - Diabetes mellitus and head and neck cancer
Grantee:Rejane Augusta de Oliveira Figueiredo
Support Opportunities: Scholarships abroad - Research Internship - Doctorate