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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The L-amino acid oxidase from Calloselasma rhodostoma snake venom modulates apoptomiRs expression in Bcr-Abl-positive cell lines

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Author(s):
Burin, Sandra Mara ; Berzoti-Coelho, Maria Gabriela ; Cominal, Jucara Gastaldi ; Ambrosio, Luciana ; Torqueti, Maria Regina ; Sampaio, Suely Vilela ; de Castro, Fabiola Attie
Total Authors: 7
Document type: Journal article
Source: Toxicon; v. 120, p. 9-14, SEP 15 2016.
Web of Science Citations: 10
Abstract

Anti-apoptotic genes and apoptomiRs deregulated expression contribute to apoptosis resistance in chronic myeloid leukemia (CML) Bcr-Abl(+) cells. Here, the L-amino acid oxidase from Calloselasma rhodostoma (CR-LAAO) venom altered the apoptotic machinery regulation by modulating the expression of the miR-145, miR-26a, miR-142-3p, miR-21, miR-130a, and miR-146a, and of the apoptosis-related proteins Bid, Bim, Bcl-2, Ciap-2, c-Flip, and Mcl-1 in Bcr-Abl(+) cells. CR-LAAO is a potential tool to instigate apoptomiRs regulation that contributes to drive CML therapy. (C) 2016 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 15/25637-7 - Epigenetic modulation of apoptotic machinery in Bcr-Abl positive cells by BmooLAAO-I and MjTX-I toxins
Grantee:Sandra Mara Burin de Menezes
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 15/23555-3 - Regulators microRNAs of Hippo pathway in chronic myeloid leukemia
Grantee:Maria Gabriela Berzoti Coelho
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 11/23236-4 - Native and recombinant animal toxins: functional, structural and molecular analysis
Grantee:Suely Vilela
Support type: Research Projects - Thematic Grants