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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Oral health, diabetes, and body weight

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Angelo Cintra, Luciano Tavares ; Samuel, Renata Oliveira ; Carrara Prieto, Annelise Katrine ; Sumida, Doris Hissako ; Dezan-Junior, Eloi ; Gomes-Filho, Joao Eduardo
Total Authors: 6
Document type: Journal article
Source: ARCHIVES OF ORAL BIOLOGY; v. 73, p. 94-99, JAN 2017.
Web of Science Citations: 9

Objectives: The effects of apical periodontitis (AP) and periodontal disease (PD) on organ weights in rats with diabetes mellitus (DM) were evaluated. Design: Eighty male rats (Rattus norvegicus albinus, Wistar) were divided into eight groups of ten: normoglycemic (N), AP, PD, AP + PD, DM, DM + AP, DM + PD, and DM + AP + PD. DM was induced by streptozotocin; AP, by dental exposure to the oral environment; and PD, by periodontal ligature. Blood glucose concentration was measured at 0, 6,15, and 35 days; body weight, measured daily; and animals were sacrificed after 30 days after induction of oral infections. Liver, kidney, pancreas, brain, heart, lungs, and gonads were each weighed. Glycemia, feed intake, organ weight, and body weight were subjected to statistical analyses (p < 0.05). Results: Glycemic levels were higher in all diabetic groups after day 6, but were consistently similar in normoglycemic groups. Blood glucose was higher in DM + PD and DM + AP + PD groups than in the DM group at days 15 and 35. The feed intake was similar among all groups. Brain, heart, and gonad weights were significantly increased in DM + AP + PD. Kidney and lung weights were increased in DM, regardless of the presence of oral infections. Liver weight was reduced in AP and/or PD. Pancreas weight was reduced in DM, independent of AP or PD. Among the normoglycemic groups, there were no significant differences among organ weights. Conclusion: Apical periodontitis and periodontal disease may potentiate the adverse effects of diabetes. (C) 2016 Published by Elsevier Ltd. (AU)

FAPESP's process: 12/02083-8 - Influence of pulpal infection associated with diabetes in the blood profile and, quantification of proinflammatory cytokines TNF-±, IL-6, IL-17. Microscopic analysis, blood measurement and study in organs of rats.
Grantee:Luciano Tavares Angelo Cintra
Support type: Regular Research Grants