| Full text | |
| Author(s): |
Furigo, Isadora C.
;
Ramos-Lobo, Angela M.
;
Frazao, Renata
;
Donato, Jr., J.
Total Authors: 4
|
| Document type: | Journal article |
| Source: | Molecular and Cellular Endocrinology; v. 438, n. C, p. 70-76, DEC 15 2016. |
| Web of Science Citations: | 6 |
| Abstract | |
Several growth factors and cytokines recruit the signal transducer and activator of transcription 5 (STAT5) signaling pathway to control cell proliferation, differentiation and apoptosis. Nonetheless, the importance of this transcription factor for brain functions is still poorly understood. Because some STAT5-inducing hormones, such as prolactin and leptin, act in the brain to regulate the expression of motivated behaviors, this signaling pathway is likely involved in behavioral modulation. Therefore, the objective of the present review was to summarize and discuss the available data regarding the possible role of central STAT5 signaling in the regulation of brain functions, especially on behavioral control. We discussed studies that investigated the importance of STAT5 signaling in the regulation of maternal and feeding behaviors. Additionally, we highlighted other behaviors that could be potentially affected by STATS signaling. This knowledge may help to understand how motivated behaviors are regulated at the cellular level. (C) 2016 Elsevier Ireland Ltd. All rights reserved. (AU) | |
| FAPESP's process: | 14/11752-6 - Study of leptin functions during intrauterine and childhood stages in mice |
| Grantee: | Angela Maria Ramos Lobo |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 12/12202-4 - Kiss1 neurons biophysical properties modulation by circadian factors |
| Grantee: | Renata Frazão |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 10/18086-0 - Molecular basis of leptin resistance |
| Grantee: | Jose Donato Junior |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 15/10992-6 - Investigation of metabolic programming through different approaches |
| Grantee: | Jose Donato Junior |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 13/07908-8 - Precocious puberty in childhood obesity: possible mechanisms and influence of leptin |
| Grantee: | Renata Frazão |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 13/21722-4 - Mechanism of action of bromocriptine and prolactin antagonists in the treatment of Diabetes and Obesity |
| Grantee: | Isadora Clivatti Furigo |
| Support Opportunities: | Scholarships in Brazil - Doctorate |