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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Brain STAT5 signaling and behavioral control

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Author(s):
Furigo, Isadora C. ; Ramos-Lobo, Angela M. ; Frazao, Renata ; Donato, Jr., J.
Total Authors: 4
Document type: Journal article
Source: Molecular and Cellular Endocrinology; v. 438, n. C, p. 70-76, DEC 15 2016.
Web of Science Citations: 6
Abstract

Several growth factors and cytokines recruit the signal transducer and activator of transcription 5 (STAT5) signaling pathway to control cell proliferation, differentiation and apoptosis. Nonetheless, the importance of this transcription factor for brain functions is still poorly understood. Because some STAT5-inducing hormones, such as prolactin and leptin, act in the brain to regulate the expression of motivated behaviors, this signaling pathway is likely involved in behavioral modulation. Therefore, the objective of the present review was to summarize and discuss the available data regarding the possible role of central STAT5 signaling in the regulation of brain functions, especially on behavioral control. We discussed studies that investigated the importance of STAT5 signaling in the regulation of maternal and feeding behaviors. Additionally, we highlighted other behaviors that could be potentially affected by STATS signaling. This knowledge may help to understand how motivated behaviors are regulated at the cellular level. (C) 2016 Elsevier Ireland Ltd. All rights reserved. (AU)

FAPESP's process: 14/11752-6 - Study of leptin functions during intrauterine and childhood stages in mice
Grantee:Angela Maria Ramos Lobo
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 12/12202-4 - Kiss1 neurons biophysical properties modulation by circadian factors
Grantee:Renata Frazão
Support Opportunities: Regular Research Grants
FAPESP's process: 10/18086-0 - Molecular basis of leptin resistance
Grantee:Jose Donato Junior
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 15/10992-6 - Investigation of metabolic programming through different approaches
Grantee:Jose Donato Junior
Support Opportunities: Regular Research Grants
FAPESP's process: 13/07908-8 - Precocious puberty in childhood obesity: possible mechanisms and influence of leptin
Grantee:Renata Frazão
Support Opportunities: Regular Research Grants
FAPESP's process: 13/21722-4 - Mechanism of action of bromocriptine and prolactin antagonists in the treatment of Diabetes and Obesity
Grantee:Isadora Clivatti Furigo
Support Opportunities: Scholarships in Brazil - Doctorate