A Current Snapshot of Common Genomic Variants Contribution in Psychiatric Disorders

Santoro, Marcos L.; Moretti, Patricia N.; Pellegrino, Renata; Gadelha, Ary; Abilio, Vanessa C.; Hayashi, Mirian A. F.; Belangero, Sintia I.; Hakonarson, Hakon

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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

A Current Snapshot of Common Genomic Variants Contribution in Psychiatric Disorders

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Author(s):	Santoro, Marcos L. ; Moretti, Patricia N. ; Pellegrino, Renata ; Gadelha, Ary ; Abilio, Vanessa C. ; Hayashi, Mirian A. F. ; Belangero, Sintia I. ; Hakonarson, Hakon Total Authors: 8
Document type:	Review article
Source:	AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS; v. 171, n. 8, p. 997-1005, DEC 2016.
Web of Science Citations:	2
Abstract
In the past decade, numerous advances were achieved in psychiatric genetics. Particularly, the genome wide association studies (GWAS) have contributed to uncovering new genes and pathways associated to psychiatric disorders (PDs). At the same time, with increasing sample sizes in the GWAS, the polygenic risk score (PRS) promoted an additional tool for identification and evaluation the genetic risk quantitatively in PDs. This concept review presents the state of the art GWAS analysis and PRS focusing on the genetic underpinnings of PDs. (C) 2016 Wiley Periodicals, Inc. (AU)

FAPESP's process:	12/50316-1 - Y-Mind: São Paulo School of Advanced Science for Prevention of Mental Disorders \| São Paulo – SP
Grantee:	Jair de Jesus Mari
Support Opportunities:	Research Grants - Scientific Meeting - São Paulo School of Advanced Science

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