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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Perinatal Exposure to Androgen Excess and the Effects on the Rat Uterine Estradiol Responsiveness

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Guerra, Marina T. ; Sanabria, Marciana ; Petrusz, Peter ; Kempinas, Wilma De Grava
Total Authors: 4
Document type: Journal article
Source: ENVIRONMENTAL TOXICOLOGY; v. 31, n. 11, p. 1460-1468, NOV 2016.
Web of Science Citations: 0

Androgen exposure during sexual development induces alterations in steroidal target tissues. The objective of this study was to evaluate the uterine responsiveness to estradiol after perinatal androgenization. Pregnant Wistar rats were exposed to corn oil or testosterone propionate at 0.05, 0.1, or 0.2 mg/kg from gestational day 12 until postnatal day 21. Female offspring was challenged with estradiol (E-2) after weaning (0.4 mg/kg) and at adulthood (10 or 100 mg/day), when the pituitary response was also evaluated. At adulthood, control and 0.05 mg/kg groups presented a uterine weight increment when exposed to 100 mg/day of E-2, 0.1 mg/kg group only responded to 10 mg/day of E-2, and the 0.2 mg/kg group showed increased uterine weight at both doses. The pituitary weight was similarly increased after estradiol stimulation in all experimental groups. In conclusion, testosterone propionate exposure induced an abnormal stimulation of uterine tissue growth by estrogen stimulus without affecting pituitary response. More studies are needed to clarify whether these alterations are capable of impairing the reproductive capacity of the female tract. (C) 2015 Wiley Periodicals, Inc. (AU)

FAPESP's process: 09/00352-9 - Structure of the genital tract and reproductive function of female rats exposed to testosterone propionate in utero and during lactation
Grantee:Marina Trevizan Guerra
Support type: Scholarships in Brazil - Doctorate