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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Fish oil prevents changes induced by a high-fat diet on metabolism and adipokine secretion in mice subcutaneous and visceral adipocytes

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da Cunha de Sa, Roberta D. C. ; Crisma, Amanda R. ; Cruz, Maysa M. ; Martins, Amanda R. ; Masi, Laureane N. ; do Amaral, Catia L. ; Curi, R. ; Alonso-Vale, Maria I. C.
Total Authors: 8
Document type: Journal article
Source: JOURNAL OF PHYSIOLOGY-LONDON; v. 594, n. 21, p. 6301-6317, NOV 2016.
Web of Science Citations: 16

In the present study, we investigated the effect of fish oil (FO) on metabolism and adipokine production by adipocytes from s.c. (inguinal; ING) and visceral (retroperitoneal; RP) white adipose depots in high-fat (HF) diet-induced obese mice. Mice were divided into CO (control diet), CO+FO, HF and HF+FO groups. The HF group presented higher body weight, glucose intolerance, insulin resistance, higher plasma total and low-density lipoprotein cholesterol levels, and greater weights of ING and RP adipose depots accompanied by hypertrophy of the adipocytes. FO exerted anti-obesogenic effects associated with beneficial effects on dyslipidaemia and insulin resistance in mice fed a HF diet (HF+FO group). HF raised RP adipocyte lipolysis and the production of pro-inflammatory cytokines and reduced de novo synthesis of fatty acids, whereas, in ING adipocytes, it decreased glucose uptake and adiponectin secretion but did not change lipolysis. Therefore, the adipose depots play different roles in HF diet-induced insulin resistance according to their location in the body. Concerning cytokine secretion, adipocytes per se in addition to white adopise tissue infiltrated leukocytes have to be considered in the aetiology of the comorbidities associated with obesity. Evidence is presented showing that previous and concomitant administration of FO can prevent changes in metabolism and the secretion of hormones and cytokines in ING and RP adipocytes induced by HF. (AU)

FAPESP's process: 10/07596-8 - Evaluation of DNA methylation changes by high-fat-induced obesity and a possible modulated efect of omega-3 fatty acids in vivo
Grantee:Cátia Lira Do Amaral
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 11/51627-8 - Effect of fat acids on the differentiation and function of the adipose tissue
Grantee:Maria Isabel Cardoso Alonso-Vale
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 10/05669-8 - Effect of supplementation with omega-3 polyunsaturated fatty acids and regular physical exercise on insulin resistance induced by high-fat diet
Grantee:Amanda Roque Martins
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 13/03268-4 - Metabolic ánd endocrine activities OF adipocytes extracted from subcutaneous ánd visceral adipose tissues OF obese animals induced by high fat diet ánd supplemented with omega 3 fatty acid
Grantee:Roberta Dourado Cavalcante da Cunha de Sá
Support type: Scholarships in Brazil - Master