Fatty acids as modulators of neutrophil recruitment, function and survival

Author(s)

Rodrigues, Hosana G. ; Sato, Fabio Takeo ; Curi, Rui ; Vinolo, Marco A. R.

• Document type: Journal article
• Source: European Journal of Pharmacology; v. 785, p. 50-58, AUG 15 2016.
• Web of Science Citations: 20

Abstract

Neutrophils are well-known to act in the destruction of invading microorganisms. They have also been implicated in the activation of other immune cells including B- and T-lymphocytes and in the resolution of inflammation and tissue regeneration. Neutrophils are produced in the bone marrow and released into the circulation from where they migrate to tissues to perform their effector functions. Neutrophils are in constant contact with fatty acids that can modulate their function, activation and fate (survival or cell death) through different mechanisms. In this review, the effects of fatty acids pertaining to five classes, namely, long-chain saturated fatty acids (LCSFAs), short-chain fatty acids (SCFAs), and omega-3 (n-3), omega-6 (n-6) and omega-9 (n-9) unsaturated fatty acids, on neutrophils and the relevance of these effects for disease development are discussed. (C) 2015 Elsevier B.V. All rights reserved. (AU)

• FAPESP's process: 12/15774-9 - Application of histone deacetylase inhibitors in the treatment of obesity and associated insulin resistance
• Grantee: Fabio Takeo Sato
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 13/06810-4 - Mechanisms of action of omega-3 and omega-6 in the tissue repair process: neuro-immune focus
• Grantee: Hosana Gomes Rodrigues
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 12/10653-9 - Role of short chain fatty acids and their receptor (GPR43) in the immune response to anaerobic bacteria in vivo and in vitro
• Grantee: Marco Aurélio Ramirez Vinolo
• Support Opportunities: Research Grants - Young Investigators Grants