Hippocampal Damage and atrophy secondary to status epilepticus in a patient with schizophrenia

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Author(s):	Fujisao, Elaine Keiko ; Cristaldo, Nathalia Raquel ; da Silva Braga, Aline Marques ; Cunha, Paulina Rodrigues ; Yamashita, Seizo ; Betting, Luiz Eduardo Total Authors: 6
Document type:	Journal article
Source:	FRONTIERS IN NEUROLOGY; v. 8, FEB 6 2017.
Web of Science Citations:	2
Abstract
A 59-year-old man was admitted with respiratory tract infection, compromised conscience and generalized tonic-clonic seizures. His medical history included schizophrenia diagnosis, for which he had been being treated since he was 27 years old. EEG disclosed non-convulsive status epilepticus. A magnetic resonance image (MRI) acquired 3 days later showed increased left hippocampal volume with hyperintensity on T2-weighted and FLAIR sequences. After being treated with antibiotics and antiepileptic medications, the patient's condition improved. A follow-up MRI showed reduction of the left hippocampus. The relationship between epilepsy and schizophrenia is not yet clear. This case illustrates this interaction. Hippocampal atrophy may have been caused by environmental aggression in the present patient with schizophrenia, perhaps in association with a predisposing genotype. (AU)

FAPESP's process:	11/02961-2 - Investigation of focal epilepsies using quantitative analysis of the video-electroencephalogram and neuroimaging
Grantee:	Luiz Eduardo Gomes Garcia Betting
Support Opportunities:	Research Grants - Young Investigators Grants