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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Mitochondrial form, function and signalling in aging

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Author(s):
Amigo, Ignacio ; da Cunha, Fernanda M. ; Forni, Maria Fernanda ; Garcia-Neto, Wilson ; Kakimoto, Pamela A. ; Luevano-Martinez, Luis A. ; Macedo, Felipe ; Menezes-Filho, Sergio L. ; Peloggia, Julia ; Kowaltowski, Alicia J.
Total Authors: 10
Document type: Review article
Source: Biochemical Journal; v. 473, n. 20, p. 3421-3449, OCT 2016.
Web of Science Citations: 11
Abstract

Aging is often accompanied by a decline in mitochondrial mass and function in different tissues. Additionally, cell resistance to stress is frequently found to be prevented by higher mitochondrial respiratory capacity. These correlations strongly suggest mitochondria are key players in aging and senescence, acting by regulating energy homeostasis, redox balance and signalling pathways central in these processes. However, mitochondria display a wide array of functions and signalling properties, and the roles of these different characteristics are still widely unexplored. Furthermore, differences in mitochondrial properties and responses between tissues and cell types, and how these affect whole body metabolism are also still poorly understood. This review uncovers aspects of mitochondrial biology that have an impact upon aging in model organisms and selected mammalian cells and tissues. (AU)

FAPESP's process: 13/07937-8 - Redoxome - Redox Processes in Biomedicine
Grantee:Ohara Augusto
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 10/51906-1 - Mitochondrial bioenergetics, ion transport, redox state and DNA metabolism
Grantee:Alicia Juliana Kowaltowski
Support type: Research Projects - Thematic Grants
FAPESP's process: 13/04919-9 - Evaluation of the adaptive response of mitochondrial membranes to stress: role of cardiolipin in membrane plasticity, dynamics and pathological situations
Grantee:Luis Alberto Luevano Martinez
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 14/17270-3 - Impact of mitochondrial dysfunction on skin aging
Grantee:Julia Peloggia de Castro
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 15/25776-7 - Mitochondrial partitioning in mammalian cells
Grantee:Maria Fernanda Pereira de Araújo Demonte Forni
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 15/15526-3 - Study of the involvement of mitochondrial activity in the super-response to caloric restriction in Caenorhabditis elegans mutants for lipl-5
Grantee:Fernanda Marques da Cunha
Support type: Regular Research Grants