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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Natural products as mediators of disease

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Author(s):
Garg, Neha ; Luzzatto-Knaan, Tal ; Melnik, Alexey V. ; Caraballo-Rodriguez, Andres Mauricio ; Floros, Dimitrios J. ; Petras, Daniel ; Gregor, Rachel ; Dorrestein, Pieter C. ; Phelan, Vanessa V.
Total Authors: 9
Document type: Review article
Source: NATURAL PRODUCT REPORTS; v. 34, n. 2, p. 194-219, FEB 1 2017.
Web of Science Citations: 22
Abstract

Humans are walking microbial ecosystems, each harboring a complex microbiome with the genetic potential to produce a vast array of natural products. Recent sequencing data suggest that our microbial inhabitants are critical for maintaining overall health. Shifts in microbial communities have been correlated to a number of diseases including infections, inflammation, cancer, and neurological disorders. Some of these clinically and diagnostically relevant phenotypes are a result of the presence of small molecules, yet we know remarkably little about their contributions to the health of individuals. Here, we review microbe- derived natural products as mediators of human disease. (AU)

FAPESP's process: 14/01651-8 - Elicitation of natural products biosynthesis from endophytic microorganisms' interactions
Grantee:Andrés Mauricio Caraballo Rodríguez
Support type: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 12/21803-1 - Elicitation of Natural Products biosintesis by endophytic microorganisms interaction
Grantee:Andrés Mauricio Caraballo Rodríguez
Support type: Scholarships in Brazil - Doctorate