Satellite cell activation induced by aerobic muscle adaptation in response to endurance exercise in humans and rodents

Author(s)

Abreu, Phablo ; Diogenes Mendes, Savio Victor ; Ceccatto, Vania Marilande ; Hirabara, Sandro Massao

• Document type: Review article
• Source: Life Sciences; v. 170, p. 33-40, FEB 1 2017.
• Web of Science Citations: 12

Abstract

Although the requirement of satellite cells activation and expansion following injury, mechanical load or growth stimulus provoked by resistance exercise has been well established, their function in response to aerobic exercise adaptation remains unclear. A clear relationship between satellite cell expansion in fiber-type specific myosin heavy chain and aerobic performance has been related, independent of myonuclear accretion or muscle growth. However, the trigger for this activation process is not fully understood yet and it seems to be a multi-faceted and well-orchestrated process. Emerging in vitro studies suggest a role for metabolic pathways and oxygen availability for satellite cell activation, modulating the self-renewal potential and cell fate control. The goal of this review is to describe and discuss the current knowledge about the satellite cell activation and expansion in response to aerobic exercise adaptation in human and rodent models. Additionally, findings about the in vitro metabolic control, which seems be involved in the satellite cell activation and cell fate control, are presented and discussed. (C) 2016 Elsevier Inc. All rights reserved. (AU)

• FAPESP's process: 11/06815-0 - Myogenesis and regeneration of skeletal muscle: possible modulation by linoleic acid
• Grantee: Phablo Sávio Abreu Teixeira
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 16/18633-8 - Expansion of satellite cell pools in adult skeletal muscle: role of bioenergetics and mitochondrial alterations induced by aerobic exercise
• Grantee: Phablo Sávio Abreu Teixeira
• Support Opportunities: Scholarships in Brazil - Post-Doctoral