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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Bioactive Glass Fiber-Reinforced PGS Matrix Composites for Cartilage Regeneration

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Author(s):
Souza, Marina Trevelin ; Tansaz, Samira ; Zanotto, Edgar Dutra ; Boccaccini, Aldo R.
Total Authors: 4
Document type: Journal article
Source: MATERIALS; v. 10, n. 1 JAN 2017.
Web of Science Citations: 8
Abstract

Poly(glycerol sebacate) (PGS) is an elastomeric polymer which is attracting increasing interest for biomedical applications, including cartilage regeneration. However, its limited mechanical properties and possible negative effects of its degradation byproducts restrict PGS for in vivo application. In this study, a novel PGS-bioactive glass fiber (F18)-reinforced composite was developed and characterized. PGS-based reinforced scaffolds were fabricated via salt leaching and characterized regarding their mechanical properties, degradation, and bioactivity in contact with simulated body fluid. Results indicated that the incorporation of silicate-based bioactive glass fibers could double the composite tensile strength, tailor the polymer degradability, and improve the scaffold bioactivity. (AU)

FAPESP's process: 13/07793-6 - CEPIV - Center for Teaching, Research and Innovation in Glass
Grantee:Edgar Dutra Zanotto
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 14/01726-8 - Development of biocomposites with bioactive glass fibers reinforcement for tissue engineering applications
Grantee:Marina Trevelin Souza
Support type: Scholarships abroad - Research Internship - Doctorate