Advanced search
Start date
Betweenand
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effects of periodontal treatment on primary sjogren's syndrome symptoms

Full text
Author(s):
Show less -
Batitucci Ambrosio, Lucas Macedo ; Rovai, Emanuel da Silva ; de Franca, Bruno Nunes ; Balzarini, Danilo Andres ; Abreu, Ieda Santos ; Bologna Lopes, Sheyla Batista ; Nunes, Thais Borguezan ; Lourenco, Silvia Vanessa ; Pasoto, Sandra Gofinet ; Saraiva, Luciana ; Holzhausen, Marinella
Total Authors: 11
Document type: Journal article
Source: Brazilian Oral Research; v. 31, 2017.
Web of Science Citations: 3
Abstract

The aim of this longitudinal prospective study was to evaluate the effects of periodontal treatment on the clinical, microbiological and immunological periodontal parameters, and on the systemic activity (ESSDAI) and subjective (ESSPRI) indexes in patients with primary Sjogren's Syndrome (pSS). Twenty-eight female patients were divided into four groups: pSS patients with or without chronic periodontitis (SCP, SC, respectively), and systemically healthy patients with or without chronic periodontitis (CP, C, respectively). Periodontal clinical examination and immunological and microbiological sample collection were performed at baseline, 30 and 90 days after nonsurgical periodontal treatment (NSPT). Levels of interleukin IL-1 beta, IL-8 and IL-10 in saliva and gingival crevicular fluid (GCF) were evaluated by ELISA, as well as the expression of Porphyromonas gingivalis (Pg), Aggregatibacter actinomycetemcomitans, (Aa) Tannerella forsythia (Tf), and Treponema denticola (Td), by qPCR. Systemic activity and pSS symptoms were evaluated by ESSDAI and ESSPRI. NSPT resulted in improved periodontal clinical parameters in both SCP and CP groups (p>0.05). Pg, Aa, and Tf levels decreased after NSPT only in CP patients (p<0.05). Significantly greater levels of IL-10 in GCF were verified in both SCP and CP groups (p<0.05). SCP patients showed increased salivary flow rates and decreased ESSPRI scores after NSPT. In conclusion, NSPT in pSS patients resulted in improved clinical and immunological parameters, with no significant effects on microbiological status. pSS patients also showed increased salivary flow and lower ESSPRI scores after therapy. Therefore, it can be suggested that NSPT may improve the quality of life of pSS patients. (AU)

FAPESP's process: 14/06387-7 - Expression of protease activated receptor 2 (PAR-2) in crevicular fluid cells of type 2-diabetic patients
Grantee:Bruno Nunes de França
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 13/26381-0 - Analysis of cytokines (in gingival fluid and serum) and periodontal pathogens (Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola) in patients with aggressive periodontitis. longitudinal study
Grantee:Luciana Saraiva
Support type: Regular Research Grants
FAPESP's process: 15/07396-2 - Effect of protease activated receptor 1 (PAR1) activation on osteogenic activity of periodontal ligament cells
Grantee:Marinella Holzhausen Caldeira
Support type: Regular Research Grants