| Full text | |
| Author(s): |
Valencia, Estela Ynes
;
Esposito, Fernanda
;
Spira, Beny
;
Blazquez, Jesus
;
Galhardo, Rodrigo S.
Total Authors: 5
|
| Document type: | Journal article |
| Source: | Antimicrobial Agents and Chemotherapy; v. 61, n. 3 MAR 2017. |
| Web of Science Citations: | 6 |
| Abstract | |
Resistance to antibiotics is a global health problem. Activation of the SOS response, and the subsequent elevation in mutagenesis, contributes to the appearance of resistance mutations. Among currently used drugs, quinolones are the most potent inducers of the SOS response. In the present study, we show that amikacin inhibits ciprofloxacin-mediated SOS induction and mutagenesis in Pseudomonas aeruginosa. (AU) | |
| FAPESP's process: | 14/15982-6 - Consequences of repair deficiencies in damaged genome |
| Grantee: | Carlos Frederico Martins Menck |
| Support Opportunities: | Research Projects - Thematic Grants |