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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Long-term effects of in utero and lactational exposure to butyl paraben in female rats

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Guerra, Marina Trevizan ; Sanabria, Marciana ; Cagliarani, Stephannie Vieira ; Araujo Leite, Gabriel Adan ; Borges, Cibele dos Santos ; Kempinas, Wilma De Grava
Total Authors: 6
Document type: Journal article
Source: ENVIRONMENTAL TOXICOLOGY; v. 32, n. 3, p. 776-788, MAR 2017.
Web of Science Citations: 6

Parabens are used as preservatives in cosmetic, pharmaceutical, and food industries, and are frequently detected as contaminants in human fluids and tissues. The endocrine disrupting effects of parabens in female rodents include uterotrophic response, steroidogenesis impairment, and ovarian disturbances. The objective of this study was to determine the effects of maternal butyl paraben (BP) exposure on female sexual development. Pregnant Wistar rats were treated subcutaneously with either corn oil or BP at doses of 10, 100, or 200mg/kg, from gestational day (GD) 12 until GD 20 for female foetal gonad evaluation, and from GD 12 until the end of lactation to evaluate sexual parameters on the female offspring. Immature female rats were also used in the uterotrophic assay to evaluate the possible estrogenic action of parabens. Our results revealed that, in this experimental protocol, BP did not show estrogenic activity at the doses used and did not impair sexual development and fertility capacity in the female rats, but impaired sexual behavior. We conclude that brain sexual development may be more sensitive to BP effects and we speculate that doses higher than 100 mg/kg (the male lowest observed adverse effect level (LOAEL) for rodent reproductive parameters) would be necessary to promote damages in the female reproduction, regarding the same protocol of exposure. (C) 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 776-788, 2017. (AU)

FAPESP's process: 13/00314-5 - Assessment of the effects of maternal exposure to butyl 4-hydroxybenzoate (butyl paraben) during gestational and lactational periods on reproductive development of wistar rats offspring
Grantee:Marina Trevizan Guerra
Support type: Scholarships in Brazil - Post-Doctorate