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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Dietary fiber and the short-chain fatty acid acetate promote resolution of neutrophilic inflammation in a model of gout in mice

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Vieira, Angelica T. ; Galvao, Izabela ; Macia, Laurence M. ; Sernaglia, Erica M. ; Vinolo, Marco Aurelio R. ; Garcia, Cristiana C. ; Tavares, Luciana P. ; Amaral, Flavio A. ; Sousa, Lirlandia P. ; Martins, Flaviano S. ; Mackay, Charles R. ; Teixeira, Mauro M.
Total Authors: 12
Document type: Journal article
Source: Journal of Leukocyte Biology; v. 101, n. 1, p. 275+, JAN 2017.
Web of Science Citations: 19

Gout is a disease characterized by the deposition of monosodium urate (MSU) crystals in the joints. Continuous gout episodes may lead to unresolved inflammatory responses and tissue damage. We investigated the effects of a high-fiber diet and acetate, a short-chain fatty acid (SCFA) resulting from the metabolism of fiber by gut microbiota, on the inflammatory response in an experimental model of gout in mice. Injection of MSU crystals into the knee joint of mice induced neutrophil influx and inflammatory hypernociception. The onset of inflammatory response induced by MSU crystals was not altered in animals given a high-fiber diet, but the high-fiber diet induced faster resolution of the inflammatory response. Similar results were obtained in animals given the SCFA acetate. Acetate was effective, even when given after injection of MSU crystals at the peak of the inflammatory response and induced caspase-dependent apoptosis of neutrophils that accounted for the resolution of inflammation. Resolution of neutrophilic inflammation was associated with decreased NF-kappa B activity and enhanced production of anti-inflammatory mediators, including IL-10, TGF-beta, and annexin A1. Acetate treatment or intake of a high-fiber diet enhanced efferocytosis, an effect also observed in vitro with neutrophils treated with acetate. In conclusion, a high-fiber diet or one of its metabolic products, acetate, controls the inflammatory response to MSU crystals by favoring the resolution of the inflammatory response. Our studies suggest that what we eat plays a determinant role in our capacity to fine tune the inflammatory response. Introduction (AU)

FAPESP's process: 14/22909-3 - Role of the short chain fatty acids and their receptor (GPR43) in the neutrophil death induced by anaerobic bacteria
Grantee:Erica Moraes Sernaglia
Support type: Scholarships in Brazil - Master
FAPESP's process: 12/10653-9 - Role of short chain fatty acids and their receptor (GPR43) in the immune response to anaerobic bacteria in vivo and in vitro
Grantee:Marco Aurélio Ramirez Vinolo
Support type: Research Grants - Young Investigators Grants