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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Relationship among alpha amylase and carbonic anhydrase VI in saliva, visible biofilm, and early childhood caries: a longitudinal study

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Borghi, Gabriela N. ; Rodrigues, Livia P. ; Lopes, Lenita M. ; Parisotto, Thais M. ; Steiner-Oliveira, Carolina ; Nobre-dos-Santos, Marines
Total Authors: 6
Document type: Journal article
Source: International Journal of Paediatric Dentistry; v. 27, n. 3, p. 174-182, MAY 2017.
Web of Science Citations: 5

Aim. This longitudinal study investigated the relationship among early childhood caries (ECC), amylase, carbonic anhydrase VI (CA VI), and the presence of visible biofilm, besides detecting if these variables could predict risk for ECC. Design. One hundred children were divided into two groups: caries group (n = 45) and caries-free group (n = 55). Visible biofilm on maxillary incisors was recorded, followed by caries diagnosis in preschoolers at baseline and at follow-up. Saliva samples were collected, and activities of CA VI and alpha amylase were determined. Data normality was assessed by Shapiro-Wilk test and then Mann-Whitney, Spearman correlation, and chi-square tests followed by multiple logistic regression analysis (alpha = 0.05, 95% confidence interval). Results. CA VI activity was significantly higher in saliva of children with caries (P <= 0.05), and alpha amylase activity was significantly higher in saliva of caries-free children (P < 0.0001). Children with alpha amylase activity in saliva lower than 122.8 U/mL (OR = 3.33 P = 0.042) and visible biofilm on maxillary incisors (OR = 3.6 P = 0.009) were more likely to develop ECC than caries-free children. A negative correlation between caries and alpha amylase activity was found (P = 0.0008). Conclusions. The presence of visible biofilm and low salivary activity of alpha amylase may be considered risk predictors for ECC. (AU)

FAPESP's process: 12/15834-1 - Analysis of concentration and activity of carbonic anhydrase VI (Ca VI) in saliva and plaque in deciduous teeth and its relationship to dental caries: longitudinal study in children 3-6 years and transverse in children 7-9 years
Grantee:Marines Nobre dos Santos Uchôa
Support type: Regular Research Grants