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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Heteroleptic tris-chelate ruthenium(II) complexes of N,N-disubstituted-N `-acylthioureas: Synthesis, structural studies, cytotoxic activity and confocal microscopy studies

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Barolli, Joao P. ; Maia, Pedro I. S. ; Colina-Vegas, Legna ; Moreira, Jane ; Plutin, Ana M. ; Mocelo, Raul ; Deflon, Victor M. ; Cominetti, Marcia R. ; Camargo-Mathias, Maria I. ; Batista, Alzir A.
Total Authors: 10
Document type: Journal article
Source: Polyhedron; v. 126, p. 33-41, APR 18 2017.
Web of Science Citations: 7

Ruthenium complexes have been assessed as anti-tumor agents against cancer cells. In this project, new heteroleptic rutheniuM(II) complexes with general formulae {[}Ru(L)(bipy)(dppb)](PF6) (where L = N,N-disubstituted-N'-acylthiourea, bipy = 2,2'-bipyridine and dppb = 1,4-bis(diphenylphosphino)butane) were synthesized and characterized by elemental analysis, IR and NMR and (H-1 and P-31[H-1]) spectroscopies, molar conductivity measurements and single crystal X-ray diffractometry. The IR and NMR data suggest the coordination of the ligands to the Ru(II) metal center through the tfiiocarbonyl and carbonyl groups. The structures of the new complexes were further studied by X-ray crystallography, which confirmed the coordination of the ligands with the metal through the sulfur and oxygen atoms, leading to the formation of distorted octahedral complexes. The N,N-disubstituted-N'-acylthioureas and their complexes were screened with respect to their in vitro cytotoxicity. All compounds exhibited considerable antipro-liferative activity against MCF-7 (human breast tumor cells ATCC HTB-26), DU-145 (human prostate tumor cells ATCC HTB-26), and relatively low toxicity against fibroblast L929 cells (health cell line from mouse ATCC CCL-1). A preliminary study regarding the mechanism of action of these compounds by con focal microscopy shows alterations of the actin filaments leading to Modifications in cytoskeletal supporting the cell death and that the cell nucleus is not main target of these complexes. (C) 2017 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 09/54011-8 - Acquisition of a single-crystal X-ray diffractometer for the structural analysis of small molecules and proteins
Grantee:Victor Marcelo Deflon
Support type: Multi-user Equipment Program
FAPESP's process: 11/21033-9 - Insecticides effects in Apis mellifera and Scaptotrigona postica (Hymenoptrera: Apidae) spermatogenesis
Grantee:Jane Carla Soares Moreira
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 11/16380-1 - Au, Re and Tc thiosemicarbazones complexes of interest in the development pharmaceuticals or radiopharmaceuticals for diagnostic or therapy
Grantee:Pedro Ivo da Silva Maia
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 13/21611-8 - Ruthenium(II) complexes coordinated to dipyridophenazine and dipyridoquinoxaline ligands: cellular assays in tumor cell lines and study of the mechanism of action for their application in anticancer therapies
Grantee:João Paulo Barolli Reis
Support type: Scholarships in Brazil - Post-Doctorate