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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Interaction of capsaicinoids with cell membrane models does not correlate with pungency of peppers

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Geraldo, Vananelia P. N. ; Ziglio, Analine C. ; Goncalves, Debora ; Oliveira, Jr., Osvaldo N.
Total Authors: 4
Document type: Journal article
Source: Chemical Physics Letters; v. 673, p. 78-83, APR 2017.
Web of Science Citations: 2

Mixed monolayers were prepared using phospholipids in order to mimic cell membranes and fractions of capsaicinoids (extracted from Malagueta, Caps-M, and Bhut Jolokia, Caps-B, peppers). According to their surface-pressure isotherms and polarization-modulated infrared reflection absorption spectra (PM-IRRAS), weak molecular-level interactions were observed between Caps and phospholipids. Both Caps-M and Caps-B penetrated into the alkyl tail region of the monolayer, interacted with the phosphate group of the phospholipids and affected hydration of their C=O groups. Since the physiological activity of Caps is not governed solely by interaction with cell membranes, it should require participation of a neuronal membrane receptor, e.g. vanilloid receptor (TRPV1). (C)2017 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 13/14262-7 - Nanostructured films from biologically-relevant materials
Grantee:Osvaldo Novais de Oliveira Junior
Support type: Research Projects - Thematic Grants
FAPESP's process: 13/04246-4 - Immobilization of dapsone in biomimetic systems: self-assembled, Langmuir and Langmuir-Blodgett films
Grantee:Vananélia Pereira Nunes Geraldo
Support type: Scholarships in Brazil - Post-Doctorate