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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Geographic heterogeneity in the prevalence of human papillomavirus in head and neck cancer

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Anantharaman, Devasena ; Abedi-Ardekani, Behnoush ; Beachler, Daniel C. ; Gheit, Tarik ; Olshan, Andrew F. ; Wisniewski, Kathy ; Wunsch-Filho, Victor ; Toporcov, Tatiana N. ; Tajara, Eloiza H. ; Levi, Jose Eduardo ; Moyses, Raquel A. ; Boccia, Stefania ; Cadoni, Gabriella ; Rindi, Guido ; Ahrens, Wolfgang ; Merletti, Franco ; Conway, David I. ; Wright, Sylvia ; Carreira, Christine ; Renard, Helene ; Chopard, Priscilia ; McKay-Chopin, Sandrine ; Scelo, Ghislaine ; Tommasino, Massimo ; Brennan, Paul ; D'Souza, Gypsyamber
Total Authors: 26
Document type: Journal article
Source: International Journal of Cancer; v. 140, n. 9, p. 1968-1975, MAY 1 2017.
Web of Science Citations: 30
Abstract

Human papillomavirus (HPV) causes oropharyngeal squamous cell carcinoma (OPSCC), although strongly divergent results have been reported regarding the prevalence of HPV16 in different countries, whether this represents important differences in etiology remains unclear. Applying rigorous protocols for sample processing, we centrally evaluated 1,420 head and neck tumors (533 oropharynx, 395 oral cavity and 482 larynx) from studies conducted in the US, Europe and Brazil for mucosal HPV DNA and p16(INK4a) expression to evaluate regional heterogeneity in the proportion of HPV16-associated OPSCC and other head and neck cancer, and to assess covariates associated with the risk of HPV16-positive OPSCC. While majority of OPSCC in the US (60%) were HPV16-positive, this proportion was 31% in Europe and only 4% in Brazil (p < 0.01). Similar differences were observed for other head and neck tumors, ranging from 7% in the US and 5% in Europe, to 0% in South America. The odds of HPV16-positive OPSCC declined with increasing pack years of smoking (OR: 0.75; 95% CI: 0.64-0.87) and drink years of alcohol use (OR: 0.64; 95% CI: 0.54-0.76). These results suggest that while the contribution of HPV16 is substantial for the oropharynx, it remains limited for oral cavity and laryngeal cancers. (AU)

FAPESP's process: 04/12054-9 - Markers of aggressive behavior in head and neck tumors
Grantee:Eloiza Helena Tajara da Silva
Support type: Research Projects - Thematic Grants
FAPESP's process: 10/51168-0 - Environmental, clinical, histopathological and molecular factors associated with development and prognosis of head and neck squamous cell carcinomas
Grantee:Eloiza Helena Tajara da Silva
Support type: Research Projects - Thematic Grants