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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The influence of benign prostatic hyperplasia on sperm morphological features and sperm DNA integrity in dogs

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Author(s):
Flores, R. B. ; Angrimani, D. S. R. ; Rui, B. R. ; Brito, M. M. ; Abreu, R. A. ; Vannucchi, C. I.
Total Authors: 6
Document type: Journal article
Source: REPRODUCTION IN DOMESTIC ANIMALS; v. 52, n. 2, SI, p. 310-315, APR 2017.
Web of Science Citations: 6
Abstract

Contents Benign prostatic hyperplasia (BPH) has a high incidence in older intact dogs. Due to the increased prostatic oxidative stress and hormonal imbalance of BPH, sperm damage can arise, such as sperm morphological alterations and DNA fragmentation. This study aimed to compare the reproductive potential of healthy dogs and those affected by benign prostatic hyperplasia. Ten dogs were assigned to two experimental groups: dogs without BPH (control; n=5) and dogs diagnosed with BPH (n=5), based on clinical signs and ultrasonographic findings. Three semen collections were performed from each dog within one month and analysed using computer-assisted sperm analysis (CASA) and functional tests. Control group showed higher percentage of sperm DNA integrity (95 +/- 1.8%) compared to the BPH group (79.2 +/- 6.4%). On the other hand, the percentage of minor sperm defects, amplitude of lateral sperm head displacement of the spermatozoa and medium sperm mitochondrial activity were higher in the BPH group. In conclusion, BPH decreases sperm DNA integrity, increases mitochondrial activity, as well as modifies sperm movement pattern. Therefore, a careful sperm analysis of aged dogs with BPH is required before a reproductive programme can be established for such patients. (AU)

FAPESP's process: 13/25966-5 - Characterization of seminal and hemodynamic changes in the prostate and testes of dogs with benign prostatic hyperplasia
Grantee:Daniel de Souza Ramos Angrimani
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 15/05419-5 - Reproductive aging in dogs: clinical and biotechnological features
Grantee:Camila Infantosi Vannucchi
Support type: Regular Research Grants