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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Exhaustive Training Leads to Hepatic Fat Accumulation

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Author(s):
da Rocha, Alisson L. ; Pinto, Ana P. ; Teixeira, Giovana R. ; Pereira, Bruno C. ; Oliveira, Luciana C. ; Silva, Adriana C. ; Morais, Gustavo P. ; Cintra, Dennys E. ; Pauli, Jose R. ; da Silva, Adelino S. R.
Total Authors: 10
Document type: Journal article
Source: Journal of Cellular Physiology; v. 232, n. 8, p. 2094-2103, AUG 2017.
Web of Science Citations: 8
Abstract

Recently, we demonstrated that an overtraining (OT) protocol for mice based on downhill running sessions increased the hepatic phosphorylation of 70-kDa ribosomal protein S6 kinase 1 (S6K1; Thr389), a downstream target of the mammalian target of rapamycin complex 1 (mTORC1). In liver, the overactivation of the Akt/mTORC1 pathway induces lipogenesis via regulation of the action of sterol regulatory element binding protein-1 (SREBP-1) at multiple steps. Herein, we verified the effects of three running OT models with same external load (i.e., the product between intensity and volume of training), but performed in downhill, uphill and without inclination, on the proteins related to the mTORC1 signaling pathway, the protein content of the SREBP-1, ACC, and FAS, and the morphological characteristics of C57BL/6 mouse livers. In summary, the downhill running-induced OT model up-regulated the levels of major proteins of the mTORC1 signaling pathway, the protein levels of SREBP-1 (p125 precursor) and induced signs of cell swelling accompanied by acute inflammation. The other two OT protocols performed uphill and without inclination did not modulate the most analyzed molecular proteins, but induced hepatic morphological alterations, suggesting an acute pathological adaptation. The three OT models induced hepatic fat accumulation. J. Cell. Physiol. 232: 2094-2103, 2017. (c) 2016 Wiley Periodicals, Inc. (AU)

FAPESP's process: 13/19985-7 - Effects of overtraining induced by exercise in treadmill without inclination, uphill and downhill on the content and activation of proteins of insulin signaling pathway and inflamation in mice
Grantee:Bruno Cesar Pereira
Support type: Scholarships in Brazil - Master
FAPESP's process: 15/08013-0 - Overreaching not functional in animal model and endoplasmic reticulum stress in muscle heart and liver
Grantee:Ana Paula Pinto
Support type: Scholarships in Brazil - Master
FAPESP's process: 14/25459-9 - Nonfunctional overreaching in animal model: inflammatory and hypertrophic adaptions of the cardiac muscle
Grantee:Alisson Luiz da Rocha
Support type: Scholarships in Brazil - Master
FAPESP's process: 15/13275-3 - Effects of overtraining protocol based on eccentric contractions on the inflammatory and Mtor pathways in the heart of C57BL/6 mice
Grantee:Gustavo Paroschi Morais
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 13/20591-3 - Responses of proteins from the inflammatory, insulinic and hypertrophic molecular pathways to nonfunctional overreaching induced by treadmill running performed in downhill, without inclination and uphill in skeletal muscle of mice
Grantee:Adelino Sanchez Ramos da Silva
Support type: Regular Research Grants