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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Susceptibility to Miltefosine in Brazilian Clinical Isolates of Leishmania (Viannia) braziliensis

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Author(s):
Espada, Caroline R. ; Ribeiro-Dias, Fatima ; Dorta, Miriam L. ; de Araujo Pereira, Ledice Inacia ; de Carvalho, Edgar M. ; Machado, Paulo R. ; Schriefer, Albert ; Yokoyama-Yasunaka, Jenicer K. U. ; Coelho, Adriano C. ; Uliana, Silvia R. B.
Total Authors: 10
Document type: Journal article
Source: American Journal of Tropical Medicine and Hygiene; v. 96, n. 3, p. 656-659, 2017.
Web of Science Citations: 2
Abstract

Leishmania (Viannia) braziliensis is the main causative species of tegumentary leishmaniasis in Brazil. In this study, we evaluated the susceptibility of 16 clinical isolates of L. (V.) braziliensis from different regions of Brazil to miltefosine in vitro. Half-maximal inhibitory concentrations of miltefosine varied from 22.9 to 144.2 mu M against promastigotes and from 0.3 to 4.2 mu M against intracellular amastigotes. No significant differences were found between isolates of different geographical origins. A clear correlation between the EC50 against promastigotes and amastigotes within each isolate was found. These findings contribute to the evaluation of miltefosine's potential and limitations for the treatment of tegumentary leishmaniasis in Brazil. (AU)

FAPESP's process: 15/05130-5 - Characterization of Leishmania (v.) braziliensis clinical isolates susceptibility to miltefosine in vitro and in vivo
Grantee:Caroline Ricce Espada
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 15/09080-2 - Evaluation of candidate drugs for the treatment of Leishmaniasis in Brazil
Grantee:Silvia Reni Bortolin Uliana
Support Opportunities: Regular Research Grants
FAPESP's process: 12/14629-5 - Mechanisms of action and resistance to miltefosine in Leishmania spp.
Grantee:Adriano Cappellazzo Coelho
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 11/20484-7 - Tamoxifen in the treatment of leishmaniasis: evaluation of efficacy in combination therapy schemes and study of the antileishmanial mechanism of action
Grantee:Silvia Reni Bortolin Uliana
Support Opportunities: Regular Research Grants