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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Distinctive role of efferocytosis in dendritic cell maturation and migration in sterile or infectious conditions

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Author(s):
Penteado, Leticia de Aquino ; Dejani, Naiara Naiana ; Verdan, Felipe Fortino ; Orlando, Allan Botinhon ; Nino, Victoria Eugenia ; Dias, Fernanda De Nuzzi ; Guerta Salina, Ana Carolina ; Medeiros, Alexandra Ivo
Total Authors: 8
Document type: Journal article
Source: IMMUNOLOGY; v. 151, n. 3, p. 304-313, JUL 2017.
Web of Science Citations: 5
Abstract

Efferocytosis, or clearance of apoptotic cells (ACs), by dendritic cells (DCs) leads to immune response suppression and tolerance to self-antigens. However, efferocytosis of infected apoptotic cells (IACs) leads to the production of a mixed pro- and anti-inflammatory cytokine milieu. We examined the DC phenotype and ability to migrate after phagocytosis of ACs or IACs and observed higher levels of CD86 and CCR7 expression in DCs, as well as enhanced migration capacity following efferocytosis of IACs. Interestingly, higher levels of interleukin-1, interleukin-10 and prostaglandin E-2 (PGE(2)) were also produced in this context. Blockage of IAC recognition led to an impaired maturation profile and PGE(2) production, which may have contributed to reduced CD86 and CCR7 expression and migration capacity. These data contribute to the understanding of how efferocytosis of sterile or infected cells may regulate the adaptive immune response, although the precise role of PGE(2) in this process requires further investigation. (AU)

FAPESP's process: 16/10964-5 - Mechanism by which PGE2 originated from efferocytosis inhibits the expression of Il-1R and Th17 differentiation - Involvement of SOCS3
Grantee:Allan Botinhon Orlando
Support type: Scholarships in Brazil - Master
FAPESP's process: 14/03967-2 - Phenotypic profile and migratory capacity of dendritic cells after apoptotic cell phagocytosis
Grantee:Letícia de Aquino Penteado
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 12/23580-0 - Differentiation of Th17 cells during phagocytosis of infected apoptotic cells: Determination of intracellular signaling pathways via PGE2 and EP receptors
Grantee:Naiara Naiana Dejani
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 11/17611-7 - Effect of efferocytosis by dendritic cells on Th17 differentiation: role of Prostaglandin E2
Grantee:Alexandra Ivo de Medeiros
Support type: Research Grants - Young Investigators Grants