| Full text | |
| Author(s): |
Roncon, Camila Marroni
;
de Melo Yamashita, Paula Shimene
;
Frias, Alana Tercino
;
Audi, Elisabeth Aparecida
;
Graeff, Frederico Guilherme
;
Coimbra, Norberto Cysne
;
Zangrossi, Helio
Total Authors: 7
|
| Document type: | Journal article |
| Source: | JOURNAL OF PSYCHOPHARMACOLOGY; v. 31, n. 6, p. 715-721, JUN 2017. |
| Web of Science Citations: | 3 |
| Abstract | |
The dorsomedial hypothalamus (DMH) and the dorsal periaqueductal gray (DPAG) have been implicated in the genesis and regulation of panic-related defensive behaviors, such as escape. Previous results point to an interaction between serotonergic and opioidergic systems within the DPAG to inhibit escape, involving mu-opioid and 5-HT1A receptors (5-HT1AR). In the present study we explore this interaction in the DMH, using escape elicited by electrical stimulation of this area as a panic attack index. The obtained results show that intra-DMH administration of the non-selective opioid receptor antagonist naloxone (0.5 nmol) prevented the panicolytic-like effect of a local injection of serotonin (20 nmol). Pretreatment with the selective -opioid receptor (MOR) antagonist CTOP (1 nmol) blocked the panicolytic-like effect of the 5-HT1AR agonist 8-OHDPAT (8 nmol). Intra-DMH injection of the selective MOR agonist DAMGO (0.3 nmol) also inhibited escape behavior, and a previous injection of the 5-HT1AR antagonist WAY-100635 (0.37 nmol) counteracted this panicolytic-like effect. These results offer the first evidence that serotonergic and opioidergic systems work together within the DMH to inhibit panic-like behavior through an interaction between mu-opioid and 5-HT1A receptors, as previously described in the DPAG. (AU) | |
| FAPESP's process: | 12/23238-0 - Evaluation of cooperative mechanisms between opioidergic and serotonergic systems in the dorsal periaqueductal grey matter in the antidepressants effects |
| Grantee: | Camila Marroni Roncon |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 10/07544-8 - Involvement of the pathway prefrontal cortex - dorsal raphe nucleus - dorsal periaqueductal gray in the regulation of defensive responses associated to the anxiety and to the panic |
| Grantee: | Paula Shimene de Melo Yamashita |
| Support Opportunities: | Scholarships in Brazil - Doctorate |