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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Mechanism and color modulation of fungal bioluminescence

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Author(s):
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Kaskova, Zinaida M. ; Dorr, Felipe A. ; Petushkov, Valentin N. ; Purtov, Konstantin V. ; Tsarkova, Aleksandra S. ; Rodionova, Natalja S. ; Mineev, Konstantin S. ; Guglya, Elena B. ; Kotlobay, Alexey ; Baleeva, Nadezhda S. ; Baranov, Mikhail S. ; Arseniev, Alexander S. ; Gitelson, Josef I. ; Lukyanov, Sergey ; Suzuki, Yoshiki ; Kanie, Shusei ; Pinto, Ernani ; Di Mascio, Paolo ; Waldenmaier, Hans E. ; Pereira, Tatiana A. ; Carvalho, Rodrigo P. ; Oliveira, Anderson G. ; Oba, Yuichi ; Bastos, Erick L. ; Stevani, Cassius V. ; Yampolsky, Ilia V.
Total Authors: 26
Document type: Journal article
Source: SCIENCE ADVANCES; v. 3, n. 4 APR 2017.
Web of Science Citations: 19
Abstract

Bioluminescent fungi are spread throughout the globe, but details on their mechanism of light emission are still scarce. Usually, the process involves three key components: an oxidizable luciferin substrate, a luciferase enzyme, and a light emitter, typically oxidized luciferin, and called oxyluciferin. We report the structure of fungal oxyluciferin, investigate the mechanism of fungal bioluminescence, and describe theuseof simple synthetic alpha-pyrones as luciferins to produce multicolor enzymatic chemiluminescence. A high-energy endoperoxide is proposed as an intermediate of the oxidation of the native luciferin to the oxyluciferin, which is a pyruvic acid adduct of caffeic acid. Luciferase promiscuity allows the use of simple alpha-pyrones as chemiluminescent substrates. (AU)

FAPESP's process: 10/11578-5 - Purification and cloning of a reductase and luciferase from bioluminescent fungi
Grantee:Anderson Garbuglio de Oliveira
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 13/07937-8 - Redoxome - Redox Processes in Biomedicine
Grantee:Ohara Augusto
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 13/16885-1 - Fungal bioluminescence: species survey, mechanistic study & toxicological assays
Grantee:Cassius Vinicius Stevani
Support type: Regular Research Grants
FAPESP's process: 12/12663-1 - Singlet molecular oxygen and peroxides in chemical biology
Grantee:Paolo Di Mascio
Support type: Research Projects - Thematic Grants
FAPESP's process: 13/07914-8 - FoRC - Food Research Center
Grantee:Bernadette Dora Gombossy de Melo Franco
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 14/14866-2 - Intermolecular interactions involving betalains
Grantee:Erick Leite Bastos
Support type: Regular Research Grants