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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

REM sleep deprivation impairs muscle regeneration in rats

Full text
Author(s):
Monico-Neto, Marcos ; Dattilo, Murilo ; Ribeiro, Daniel Araki ; Lee, Kil Sun ; de Mello, Marco Tulio ; Tufik, Sergio ; Moreira Antunes, Hanna Karen
Total Authors: 7
Document type: Journal article
Source: GROWTH FACTORS; v. 35, n. 1, p. 12-18, 2017.
Web of Science Citations: 3
Abstract

Introduction: The aim was observe the influence of sleep deprivation (SD) and sleep recovery on muscle regeneration process in rats submitted to cryolesion. Methods: Thirty-two Wistar rats were randomly allocated in four groups: control (CTL), SD for 96 h (SD96), control plus sleep recovery period (CTL + R) and SD96h plus 96 h of sleep recovery (SD96 + R). The animals were submitted to muscle injury by cryolesioning, after to SD and sleep recovery. Results: The major outcomes of this study were the reduction of muscular IGF-1 in both legs (injured and uninjured) and a delay in muscle regeneration process of animals submitted to SD compared to animals that slept, with increase connective tissue, inflammatory infiltrate and minor muscle fibers. Conclusions: SD impairs muscle regeneration in rats, moreover reduces muscular IGF-1 and sleep recovery was able to restore it to basal levels, but it was not enough to normalize the muscle regeneration. (AU)

FAPESP's process: 13/00152-5 - Effect of resistance exercise in cardiac and skeletal muscle of Wistar rats submitted to paradoxical sleep deprivation
Grantee:Hanna Karen Moreira Antunes
Support Opportunities: Regular Research Grants
FAPESP's process: 09/11056-1 - Effects of sleep deprivation in muscle recovery
Grantee:Murilo Dattilo
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 11/15962-7 - Effects of resistance exercise on trophic and atrophic patways in skeletal muscle of rats with paradoxal sleep deprivation
Grantee:Marcos Mônico Neto
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 98/14303-3 - Center for Sleep Studies
Grantee:Sergio Tufik
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC