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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Synthesis of 1-((4-methoxyphenyl)-3-alkynes)-1H-pyrrole-2,5-diones and functionalization to triazoles

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Ali, Bakhat ; Vasconcelos, Stanley N. S. ; Shamim, Anwar ; Zukerman-Schpector, J. ; Stefani, Helio A.
Total Authors: 5
Document type: Journal article
Source: ARABIAN JOURNAL OF CHEMISTRY; v. 10, n. 4, p. 500-508, MAY 2017.
Web of Science Citations: 0

A series of alkynyl maleimides were prepared via one-step cross-coupling reaction using bromomaleimide and acetylenes under the Sonogashira conditions, affording 1-((4-methoxyphenyl)-3-alkynes)-1H-pyrrole-2,5-diones in good to high yields. These products were subsequently converted in the corresponding 1,2,3-triazole using conventional click chemistry approach. The alkynyl maleimide compound (8g) crystallized in the triclinic space group P1 with unit cell parameters a = 5.3692(6), b = 9.2513(10), c = 10.3070(11) angstrom, alpha = 85.349(4), beta = 86.892(4), gamma = 86.892(4)degrees, V = 507.31(10) angstrom(3), and Z = 1. In the crystal the molecules are stacked parallel to the c axis and held together through a C-H...pi and a C-H...O interaction. (C) 2016 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University. (AU)

FAPESP's process: 12/00424-2 - Synthesis of small libraries using potassium Organotrifluoroborates in Suzuki-Miyaura reactions
Grantee:Helio Alexandre Stefani
Support type: Research Projects - Thematic Grants
FAPESP's process: 12/17954-4 - Cyclization reaction of Acetyl- and Ethylpyrrolidin-2-one with potassium organotrifluoroborate salts
Grantee:Bakhat Ali
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 13/17960-7 - Functionalization of 3-iodo-(L)-Tyrosine via Suzuki-Miyaura reaction using potassium organotrifluoroborate salts
Grantee:Stanley Nunes Siqueira Vasconcelos
Support type: Scholarships in Brazil - Doctorate