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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Tailored Silica Nanoparticles Surface to Increase Drug Load and Enhance Bactericidal Response

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Luciane F. de Oliveira ; Karim Bouchmella ; Agustin S. Picco ; Larissa B. Capeletti ; Kaliandra A. Gonçalves ; João Henrique Z. dos Santos ; Jörg Kobarg ; Mateus B. Cardoso
Total Authors: 8
Document type: Journal article
Source: Journal of the Brazilian Chemical Society; v. 28, n. 9, p. -, Set. 2017.

Nanoparticles' surface properties can be used as triggers to regulate or even enhance biological response and generate tailored structures to substitute conventional antibiotics. Here, silica nanoparticles surface was duly tuned in order to increase the water-insoluble drug load (curcumin) and improve the antibacterial activity. Our main motivation was based on the electrostatic attraction between the positively charged amino groups and the negatively charged curcumin and/or bacteria membrane. In addition, the variation of amino grafting amount on silica nanoparticles indicated that the grafting increase was directly related to the extent of drug entrapped into the nanoparticles as well as to the bactericidal activity. The combination of amino-functionalized silica nanoparticles associated with the presence of curcumin allowed to produce a dual bactericidal system that shows promising perspective for its use in biomedical applications. (AU)

FAPESP's process: 15/25406-5 - Organizing matter: colloids formed by association of surfactants, polymers and nanoparticles
Grantee:Watson Loh
Support type: Research Projects - Thematic Grants
FAPESP's process: 14/22322-2 - Functionalization of silica nanoparticles: increasing biological interaction
Grantee:Mateus Borba Cardoso
Support type: Regular Research Grants