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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

"Photo" Chemistry Without Light?

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Author(s):
Wilhelm J. Baader [1] ; Cassius V. Stevani [2] ; Etelvino J. H. Bechara [3]
Total Authors: 3
Affiliation:
[1] Universidade de São Paulo. Instituto de Química. Departamento de Química Fundamental - Brasil
[2] Universidade de São Paulo. Instituto de Química. Departamento de Química Fundamental - Brasil
[3] Universidade de São Paulo. Instituto de Química. Departamento de Química Fundamental - Brasil
Total Affiliations: 3
Document type: Journal article
Source: Journal of the Brazilian Chemical Society; v. 26, n. 12, p. 2430-2447, 2015-12-00.
Abstract

In the early seventies, Giuseppe Cilento (São Paulo University), Emil White (Johns Hopkins University) and Angelo Lamola (AT&T Bell Laboratories) postulated that typical photochemical reactions could occur in dark parts of living organisms if coupled to enzymatic sources of electronically excited products. Their paradoxical hypothesis of "photochemistry without light" was chemically anchored on the synthesis and weak chemiluminescence of several 1,2-dioxetanes, unstable cyclic peroxides whose thermal cleavage produces long-lived and reactive triplet carbonyls. Collisional reactions or energy transfer of triplet species to cellular targets could eventually result in "photo" products that potentially trigger normal or pathological responses. These ideas flourished in the labs of various researchers who attempted to explain the presence and biological roles of "dark" secondary metabolites, including plant hormones, pyrimidine dimers, alkaloid lumi-isomers, protein adducts, and mitochondrial permeators, thereby broadening the field of photobiology. (AU)

FAPESP's process: 14/22136-4 - Use of green solvents and their mixtures for optimizing chemical processes
Grantee:Omar Abou El Seoud
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 08/57721-3 - Redoxome
Grantee:Ohara Augusto
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 13/16885-1 - Fungal bioluminescence: species survey, mechanistic study & toxicological assays
Grantee:Cassius Vinicius Stevani
Support Opportunities: Regular Research Grants
FAPESP's process: 06/56530-4 - Carbonilic and redox stress associated with alpha-aminoketones and endogenous beta-ketoacids: mechanisms and biomarkers.
Grantee:Etelvino José Henriques Bechara
Support Opportunities: Research Projects - Thematic Grants