| Full text | |
| Author(s): |
Diego D. Bou
[1]
;
Augusto L. dos Santos
[2]
;
Carlos R. Figueiredo
[3]
;
Camyla F. Farias
[4]
;
Alisson L. Matsuo
[5]
;
Rodrigo O. S. Kitamura
[6]
;
Leila Gimenes
[7]
;
João H. G. Lago
[8]
;
Patricia Sartorelli
[9]
Total Authors: 9
|
| Affiliation: | [1] Universidade Federal de São Paulo. Instituto de Ciências Ambientais, Químicas e Farmacêuticas - Brasil
[2] Universidade Federal de São Paulo. Instituto de Ciências Ambientais, Químicas e Farmacêuticas - Brasil
[3] Universidade Federal de São Paulo. Instituto de Ciências Ambientais, Químicas e Farmacêuticas - Brasil
[4] Universidade Federal de São Paulo. Departamento de Micro, Imuno e Parasitologia - Brasil
[5] Universidade Federal de São Paulo. Departamento de Micro, Imuno e Parasitologia - Brasil
[6] Universidade Federal de São Carlos. Departamento de Química - Brasil
[7] Universidade Federal de São Carlos. Departamento de Química - Brasil
[8] Universidade Federal de São Paulo. Instituto de Ciências Ambientais, Químicas e Farmacêuticas - Brasil
[9] Universidade Federal de São Paulo. Instituto de Ciências Ambientais, Químicas e Farmacêuticas - Brasil
Total Affiliations: 9
|
| Document type: | Journal article |
| Source: | Journal of the Brazilian Chemical Society; v. 26, n. 8, p. 1725-1729, 2015-08-00. |
| Abstract | |
<p>A new clerodane-type diterpene, named dinor casearin X, and four known casearins (A, B, G and J) were isolated from leaves of <italic>Casearia sylvestris</italic>(Salicaceae). These compounds were evaluated for cytotoxic activity against five human cancer cell lines (A2058, HL-60, HCT, MCF-7 and HeLa) as well as against a murine melanoma cell line (B16F10-Nex2). Among these compounds, dinor casearin X exhibited the highest cytotoxic activity against HL-60 cells with IC<sub>50</sub> of 0.51 ± 0.11 µg mL<sup>-1</sup>, whereas casearin A exhibited the highest cytotoxic activity against HCT cells (IC<sub>50</sub> 1.84 ± 0.14 µg mL<sup>-1</sup>).</p> (AU) | |
| FAPESP's process: | 11/51739-0 - Sustainable use of biodiversity in Atlantic Forest remnants in São Paulo: evaluation, isolation and molecular characterization of bioactive secondary metabolites in plant species |
| Grantee: | João Henrique Ghilardi Lago |
| Support Opportunities: | BIOTA-FAPESP Program - Regular Research Grants |
| FAPESP's process: | 13/16320-4 - Prospection of anti-parasitic and anti-tumor metabolites from plant species of the Atlantic Forest |
| Grantee: | Patricia Sartorelli |
| Support Opportunities: | Regular Research Grants |