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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Efficacy of piroxicam for postoperative pain after lower third molar surgery associated with CYP2C8{*}3 and CYP2C9

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Calvo, Adriana Maria ; Zupelari-Goncalves, Paulo ; Dionisio, Thiago Jose ; Brozoski, Daniel Thomas ; Faria, Flavio Augusto ; Santos, Carlos Ferreira
Total Authors: 6
Document type: Journal article
Source: JOURNAL OF PAIN RESEARCH; v. 10, p. 1581-1589, 2017.
Web of Science Citations: 2

Objective: Nonsteroidal anti-inflammatory drugs (NSAIDs) are metabolized by the cytochrome P450 enzymes (CYPs), predominantly CYP2C8 and CYP2C9. The aim of this study was to evaluate the possible association of polymorphisms in the CYP2C8{*}3 and CYP2C9 genes with the clinical efficacy of oral piroxicam (20 mg daily for 4 days) after lower third molar surgeries with regard to postoperative pain, swelling, trismus, adverse reactions, need for rescue medication and the volunteer's overall satisfaction. Materials and methods: For this purpose, 102 volunteers were genotyped for CYP2C8{*}3 and CYP2C9 polymorphisms. Briefly, genomic DNA was isolated from saliva collected from volunteers subjected to invasive lower third molar surgeries, and the preoperative, intraoperative and postoperative parameters were collected and analyzed. Results: An equal amount of piroxicam sufficiently managed postoperative pain and inflammatory symptoms, with visual analog pain scores typically < 40 mm for all genotypes investigated. Furthermore, only two out of 102 volunteers heterozygous for CYP2C8{*}3 and CYP2C9{*}3 reported adverse side effects. Conclusion: In general, slow metabolizers of piroxicam, who were volunteers with mutant alleles, were indifferent from normal metabolizers with the wild-type alleles and therefore did not require specialized piroxicam doses to manage postoperative pain and inflammation. (AU)

FAPESP's process: 09/17851-8 - Influence of cytochrome P450 (CYP2C9) genotype on the clinical efficacy and pharmacokinetics of piroxicam after lower third molar surgery
Grantee:Adriana Maria Calvo
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 14/17803-1 - Influence of genotype of cytochrome P450 (CYP2C9) on the clinical efficacy and pharmacokinetics of Piroxicam after lower third molar surgery
Grantee:Carlos Ferreira dos Santos
Support type: Regular Research Grants