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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

DNA repair genes PAXIP1 and TP53BP1 expression is associated with breast cancer prognosis

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De Gregoriis, Giuliana ; Ramos, Juliene Antonio ; Fernandes, Priscila Valverde ; Vignal, Giselle Maria ; Brianese, Rafael Canfield ; Carraro, Dirce Maria ; Monteiro, Alvaro N. ; Struchiner, Claudio Jose ; Suarez-Kurtz, Guilherme ; Vianna-Jorge, Rosane ; de Carvalho, Marcelo Alex
Total Authors: 11
Document type: Journal article
Source: CANCER BIOLOGY & THERAPY; v. 18, n. 6, p. 439-449, 2017.
Web of Science Citations: 2
Abstract

Despite remarkable advances in diagnosis, prognosis and treatment, advanced or recurrent breast tumors have limited therapeutic approaches. Many treatment strategies try to explore the limitations of DNA damage response (DDR) in tumor cells to selectively eliminate them. BRCT (BRCA1 C-terminal) domains are present in a superfamily of proteins involved in cell cycle checkpoints and the DDR. Tandem BRCT domains (tBRCT) represent a distinct class of these domains. We investigated the expression profile of 7 tBRCT genes (BARD1, BRCA1, LIG4, ECT2, MDC1, PAXIP1/PTIP and TP53BP1) in breast cancer specimens and observed a high correlation between PAXIP1 and TP53BP1 gene expression in tumor samples. Tumors with worse prognosis (tumor grade 3 and triple negative) showed reduced expression of tBRCT genes, notably, PAXIP1 and TP53BP1. Survival analyses data indicated that tumor status of both genes may impact prognosis. PAXIP1 and 53BP1 protein levels followed gene expression results, i.e., are intrinsically correlated, and also reduced in more advanced tumors. Evaluation of both genes in triple negative breast tumor samples which were characterized for their BRCA1 status showed that PAXIP1 is overexpressed in BRCA1 mutant tumors. Taken together our findings indicate that PAXIP1 status correlates with breast cancer staging, in a manner similar to what has been characterized for TP53BP1. (AU)

FAPESP's process: 13/23277-8 - Molecular aspects involved in the development and progression of breast ductal carcinoma: investigation of carcinoma in situ progression and the role of BRCA1 mutation in the triple negative tumor
Grantee:Dirce Maria Carraro
Support type: Research Projects - Thematic Grants