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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Prognostic biomarkers in oral squamous cell carcinoma: A systematic review

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Author(s):
Rivera, Cesar ; Oliveira, Ana Karina ; Pereira Costa, Rute Alves ; De Rossi, Tatiane ; Paes Leme, Adriana Franco
Total Authors: 5
Document type: Review article
Source: Oral Oncology; v. 72, p. 38-47, SEP 2017.
Web of Science Citations: 18
Abstract

Over the years, several tumor biomarkers have been suggested to foresee the prognosis oral squamous cell carcinoma (OSCC) patients. Here, we present a systematic review to identify, evaluate and summarize the evidence for OSCC reported markers. Eligible studies were identified through a literature search of MEDLINE/PubMed until January 2016. We included primary articles reporting overall survival, diseasefree survival and cause-specific survival as outcomes. Our findings were analysed using REporting recommendations for tumor MARKer prognostic studies (REMARK), QuickGo tool and SciCurve trends. We found 41 biomarkers, mostly proteins evaluated by immunohistochemistry. The selected studies are of good quality, although, any study referred to a sample size determination. Considering the lack of follow-up studies, the molecules are still potential biomarkers. Further research is required to validate these biomarkers in well-designed clinical cohort-based studies. (C) 2017 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 15/12431-1 - Verification of saliva proteins candidates for markers in OSCC and its correlation with prognosis
Grantee:Tatiane de Rossi Mazo
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 16/07846-0 - Peptidomic analysis of extracelular vesicles originated from cell lines, saliva and plasma from oral squamous cell carcinoma
Grantee:Adriana Franco Paes Leme
Support type: Regular Research Grants
FAPESP's process: 14/06485-9 - Investigation of the ADAM17 metalloproteinase regulation mechanism by the interaction with Trx-1
Grantee:Rute Alves Pereira e Costa
Support type: Scholarships in Brazil - Post-Doctorate