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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Thymus vulgaris L. and thymol assist murine macrophages (RAW 264.7) in the control of in vitro infections by Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans

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Author(s):
de Oliveira, Jonatas Rafael ; Figueira, Leandro Wagner ; Sper, Fabia Lugli ; Meccatti, Vanessa Marques ; Afonso Camargo, Samira Esteves ; de Oliveira, Luciane Dias
Total Authors: 6
Document type: Journal article
Source: IMMUNOLOGIC RESEARCH; v. 65, n. 4, p. 932-943, AUG 2017.
Web of Science Citations: 2
Abstract

Microorganisms are capable to combat defense cells by means of strategies that contribute to their stabilization and proliferation in invaded tissues. Frequently antimicrobial-resistant strains appear; therefore, alternative methods to control them must be investigated, for example, the use of plant products. The capacity of the thyme extract (Thymus vulgaris L.) and phytocompound thymol in the control of in vitro infections by Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans in murine macrophages (RAW 264.7) was evaluated. Minimal inhibitory concentrations (MIC) of the plant products were used. The effect of these MIC were analyzed in the assays of phagocytosis and immunoregulation by analysis of the production of cytokines (IL-1 beta, TNF-alpha, and IL-10) and nitric oxide (NO). The plant products effectively assisted the macrophages in the phagocytosis of microorganisms, presenting significant reductions of S. aureus and P. aeruginosa. The macrophages also regulated the production of inflammatory mediators in the infections by S. aureus, P. aeruginosa, and C. albicans. In addition, thyme provided a satisfactory effect in response to the bacterial infections, regarding generation of NO. Thus, the effectiveness of the thyme and thymol to control in vitro infections by S. aureus, P. aeruginosa, and C. albicans was observed. (AU)

FAPESP's process: 15/08776-3 - ANTIMICROBIAL AND ANTI-INFLAMMATORY ACTIVITY, CYTOTOXICITY AND GENOTOXICITY OF DIFFERENT NATURAL EXTRACTS
Grantee:Luciane Dias de Oliveira
Support Opportunities: Regular Research Grants