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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Yacon (Smallanthus sonchifolius) Leaf Extract Attenuates Hyperglycemia and Skeletal Muscle Oxidative Stress and Inflammation in Diabetic Rats

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dos Santos, Klinsmann Carolo ; Bueno, Bianca Guerra ; Pereira, Luana Ferreira ; Francisqueti, Fabiane Valentini ; Braz, Mariana Gobbo ; Bincoleto, Lahis Fernandes ; da Silva, Lilian Xavier ; Ferreira, Ana Lucia A. ; de Melo Stevanato Nakamune, Ana Claudia ; Chen, C. -Y. Oliver ; Blumberg, Jeffrey B. ; Correa, Camila Renata
Total Authors: 12
Document type: Journal article
Source: Evidence-based Complementary and Alternative Medicine; 2017.
Web of Science Citations: 1

Theeffects of hydroethanolic extract of Yacon leaves (HEYL) on antioxidant, glycemic, and inflammatory biomarkers were tested in diabetic rats. Outcome parameters included glucose, insulin, interleukin-6 (IL-6), and hydrophilic antioxidant capacity (HAC) in serum and IL-6, HAC, malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in soleus. The rats (10/group) were divided as follows: C, controls; C + Y, HEYL treated; DM, diabetic controls; and DM + Y, diabetic rats treated with HEYL. Diabetes mellitus was induced by administration of streptozotocin. C + Y and DM + Y groups received 100 mg/kg HEYL daily via gavage for 30 d. Hyperglycemia was improved in the DM + Y versus DM group. Insulin was reduced in DM versus C group. DM rats had higher IL-6 and MDA and lower HAC in the soleus muscle. HEYL treatment decreased IL-6 and MDA and increased HAC in DM rats. DM + Y rats had the highest CAT activity versus the other groups; GPx was higher in C + Y and DM + Y versus their respective controls. The apparent benefit of HEYL may be mediated via improving glucoregulation and ameliorating oxidative stress and inflammation, particularly in diabetic rats. (AU)

FAPESP's process: 14/17364-8 - Effect of leaf extract of Smallanthus sonchifolius (Yacon) on metabolic changes in skeletal muscle of rats with experimental Diabetes Mellitus
Grantee:Bianca Guerra Bueno
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 15/10626-0 - Interrelation of gamma-oryzanol and activation of adipose R1 and R2 adipose receptors: possible effect on improvement of obesity-associated renal function
Grantee:Camila Renata Corrêa
Support type: Regular Research Grants