| Full text | |
| Author(s): Show less - |
Santos-Almeida, Fernanda Machado
;
Domingos-Souza, Gean
;
Meschiari, Cesar A.
;
Favaro, Laura Campos
;
Becari, Christiane
;
Castania, Jaci A.
;
Lopes, Alexandre
;
Cunha, Thiago M.
;
Moraes, Davi J. A.
;
Cunha, Fernando Q.
;
Ulloa, Luis
;
Kanashiro, Alexandre
;
Tezini, Geisa C. S. V.
;
Salgado, Helio C.
Total Authors: 14
|
| Document type: | Journal article |
| Source: | SCIENTIFIC REPORTS; v. 7, JUL 24 2017. |
| Web of Science Citations: | 3 |
| Abstract | |
Recent studies demonstrated a critical functional connection between the autonomic (sympathetic and parasympathetic) nervous and the immune systems. The carotid sinus nerve (CSN) conveys electrical signals from the chemoreceptors of the carotid bifurcation to the central nervous system where the stimuli are processed to activate sympathetic and parasympathetic efferent signals. Here, we reported that chemoreflex activation via electrical CSN stimulation, in conscious rats, controls the innate immune response to lipopolysaccharide attenuating the plasma levels of inflammatory cytokines such as tumor necrosis factor (TNF), interleukin 1 beta (IL-1 beta) and interleukin 6 (IL-6). By contrast, the chemoreflex stimulation increases the plasma levels of anti-inflammatory cytokine interleukin 10 (IL-10). This chemoreflex anti-inflammatory network was abrogated by carotid chemoreceptor denervation and by pharmacological blockade of either sympathetic - propranolol - or parasympathetic -methylatropine-signals. The chemoreflex stimulation as well as the surgical and pharmacological procedures were confirmed by real-time recording of hemodynamic parameters {[}pulsatile arterial pressure (PAP) and heart rate (HR)]. These results reveal, in conscious animals, a novel mechanism of neuromodulation mediated by the carotid chemoreceptors and involving both the sympathetic and parasympathetic systems. (AU) | |
| FAPESP's process: | 13/06452-0 - CARDIOVASCULAR REGULATION IN MICE WITH ATTENUATION OR OVEREXPRESSION OF THE GENE OF VESICULAR ACETYLCHOLINE TRANSPORTER (VAChT): PARASYMPATHETIC FUNCTION IN HEART FAILURE. |
| Grantee: | GEISA CRISTINA SINGOLANI VACCARI TEZINI REIS |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 13/20549-7 - New insights in cardiovascular regulation under physiological and pathophysiological condition |
| Grantee: | Helio Cesar Salgado |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 11/20343-4 - Antiinflammatory cholinergic pathway: the role of neuroimmunomodulation in the control of inflammatory response |
| Grantee: | Alexandre Kanashiro |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 13/26217-6 - Effect of acetylcholinesterase inhibition on connexin 43 preservation in the heart of rats with acute myocardial infarction |
| Grantee: | Fernanda Machado Santos de Almeida |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 13/13269-8 - Effects of chronic electrical stimulation of carotid sinus in cardiovascular function in spontaneously hypertensive rats |
| Grantee: | Gean Domingos da Silva Souza |
| Support Opportunities: | Scholarships in Brazil - Doctorate |