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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

``On Water{''} Metal-Catalyst-Free Oxidative Coupling-Amidation of Amines To Access Imines and Amides

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de Souza, Gabriela F. P. ; von Zuben, Theodora W. ; Salles, Jr., Airton G.
Total Authors: 3
Document type: Journal article
Source: ACS SUSTAINABLE CHEMISTRY & ENGINEERING; v. 5, n. 9, p. 8439-8446, SEP 2017.
Web of Science Citations: 8

A simple route toward the selective synthesis of imines and amides through oxidative couplingoxidative amidation of amines using widely available NaOCl is presented. Under this approach, unprecedented one-pot synthesis of symmetrical and unsymmetrical secondary amides from primary amines as a single starting material is reported. This metal-catalyst-free protocol relies upon on water acceleration to obtain the desired products in high yields. An additive-based robustness screen was conducted to demonstrate the high reaction tolerance to several chemical motifs. Furthermore, mechanistic studies support a proposed pathway for the targeted oxidation products. (AU)

FAPESP's process: 15/12305-6 - Supramolecular catalysis in water: probing the influence of a tetrahedral cage on photocyclization and photooxidation
Grantee:Airton Goncalves Salles Junior
Support type: Regular Research Grants