Bariatric Surgery and Precision Nutrition - BV FAPESP
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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Bariatric Surgery and Precision Nutrition

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Author(s):
Nicoletti, Carolina F. [1] ; Cortes-Oliveira, Cristiana [1] ; Pinhel, Marcela A. S. [1, 2] ; Nonino, Carla B. [1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Internal Med, BR-14049900 Sao Paulo - Brazil
[2] Sao Jose do Rio Preto Med Sch, Dept Mol Biol, BR-15090000 Sao Paulo - Brazil
Total Affiliations: 2
Document type: Review article
Source: NUTRIENTS; v. 9, n. 9 SEP 2017.
Web of Science Citations: 10
Abstract

This review provides a literature overview of new findings relating nutritional genomics and bariatric surgery. It also describes the importance of nutritional genomics concepts in personalized bariatric management. It includes a discussion of the potential role bariatric surgery plays in altering the three pillars of nutritional genomics: nutrigenetics, nutrigenomics, and epigenetics. We present studies that show the effect of each patient's genetic and epigenetic variables on the response to surgical weight loss treatment. We include investigations that demonstrate the association of single nucleotide polymorphisms with obesity phenotypes and their influence on weight loss after bariatric surgery. We also present reports on how significant weight loss induced by bariatric surgery impacts telomere length, and we discuss studies on the existence of an epigenetic signature associated with surgery outcomes and specific gene methylation profile, which may help to predict weight loss after a surgical procedure. Finally, we show articles which evidence that bariatric surgery may affect expression of numerous genes involved in different metabolic pathways and consequently induce functional and taxonomic changes in gut microbial communities. The role nutritional genomics plays in responses to weight loss after bariatric surgery is evident. Better understanding of the molecular pathways involved in this process is necessary for successful weight management and maintenance. (AU)

FAPESP's process: 16/05638-1 - Whole-genome DNA methylation profiling before and after different obesity treatments
Grantee:Carla Barbosa Nonino
Support Opportunities: Regular Research Grants
FAPESP's process: 13/12819-4 - Genetic, clinical, biochemical and heart rate variability changes in grade III Obesity pre and post bariatric surgery
Grantee:Marcela Augusta de Souza Pinhel
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 15/18669-0 - Whole-genome DNA methylation profiling before and after Roux-en-Y gastric bypass
Grantee:Carolina Nicoletti Ferreira Fino
Support Opportunities: Scholarships in Brazil - Post-Doctoral